Search for dissertations about: "mouse genetics"
Showing result 11 - 15 of 118 swedish dissertations containing the words mouse genetics.
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11. Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis
Abstract : Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. READ MORE
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12. Spermatological irradiation and the genetic consequences in a mouse population
Abstract : .... READ MORE
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13. PDGF in cerebellar development and tumorigenesis
Abstract : Medulloblastoma is a highly malignant cerebellar childhood tumor. As in many other brain tumors, expression of platelet-derived growth factor (PDGF) and its receptors has been shown in medulloblastoma. READ MORE
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14. Roles of p16INk a and PDGF-B in glioma
Abstract : Gliomas are diffuse astrocytic tumors of the central nervous system (CNS) which usually affect adults. This thesis work has focused on molecular mechanisms of altered growth control in glioma, and the significance of two gene products belonging to pathways commonly affected in glioma, p16INK4a and PDGF-B, has been investigated in vitro and in vivo. READ MORE
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15. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo
Abstract : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. READ MORE