Search for dissertations about: "mouse models"

Showing result 1 - 5 of 623 swedish dissertations containing the words mouse models.

2. 1. Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models

   Author : Henrik Gezelius; Klas Kullander; Ted Ebendal; Martyn Goulding; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acetyl choline; central nervous system; central pattern generator; Cre recombinase; development; genetic screen; glutamate; interneuron; motor neuron; mouse; mouse genetics; movement; network; neuronal network; nicotinic receptors; physiology; Renshaw cell; rhythm; spinal cord; transmitter; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi; Neurophysiology; Neurofysiologi; Neurobiology; Neurobiologi; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

   Abstract : Spinal neurons are important in several aspects motor control. For example, the neurons essential for locomotor movements reside in the ventral spinal cord. In this thesis, different motor control functions are being related to neuronal populations defined by their common expression of a gene. READ MORE

4. 2. Non-invasive ultrasound-based cardiovascular imaging in mouse models of atherosclerosis

   Author : Julia Grönros; Göteborgs universitet; []
   Keywords : atherosclerosis; ultrasound-based imaging; cardiovascular disease; coronary artery; mouse; color Doppler echocardiography; ultrasound biomicroscopy; statin;

   Abstract : Atherosclerosis is a chronic multi-factorial vascular disease. It generally requires large clinical settings and over many years to study the disease progression in man. Genetically modified mouse models of atherosclerosis have dramatically increased research feasibility within this area. READ MORE

5. 3. Microdosimetry of radiohalogens in thyroid models

   Author : Anders Josefsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microdosimetry; radiohalogens; radioiodine; astatine-211; thyroid gland; man; rat; mouse;

   Abstract : The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with the possibility to bind them to the same carrier molecule, give many advantages, for example, by enabling relevant biodistribution and dosimetric studies important for dose-planning before radionuclide therapy. READ MORE

6. 4. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

   Author : Björn Jansson; Erik Björk; Sveinbjörn Gizurarson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Administration; intranasal; Nasal mucosa; Central nervous system; Olfactory bulb; Rat; Mouse; Swine; Cattle; Diffusion chambers; culture; In vitro; Biological models; Biological transport; Dextrans; Dopamine; Gels; Polysaccharides; Autoradiography; Fluorescence microscopy; Biofarmaci; Biopharmacy; Biofarmaci;

   Abstract : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. READ MORE

7. 5. Development of Novel Models for Studying Osteoclasts

   Author : Christian Thudium; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoclast; Osteopetrosis; Osteoporosis; Bone; Hematopoiesis; Gene Therapy; Mouse Models; oc oc; RANK KO;

   Abstract : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. READ MORE