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Showing result 1 - 5 of 111 swedish dissertations matching the above criteria.

  2. 1. Molecular and structural studies of proteins required for mitochondrial DNA maintenance

    Author : Carlos Pardo-Hernandez; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mtDNA; LONP1; POLγ; mtDNA maintenance; mitochondrial disease; TWINKLE; mitochondria;

    Abstract : Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), which codes for thirteen proteins needed for oxidative phosphorylation (OXPHOS). READ MORE

  4. 2. Crisis in Energy Metabolism - Mitochondrial Defects and a New Disease Entity

    Author : Gittan Kollberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase gamma;

    Abstract : Impairment of energy metabolism may be associated with severe implications for affected individuals since all fundamental cell functions are energy-dependent. Disorders of energy metabolism are often genetic and associated with defects in the oxidative phosphorylation in mitochondria. READ MORE

  5. 3. Analysis of the origin and spread of the domestic dog using Y-chromosome DNA and mtDNA sequence data

    Author : Mattias Oskarsson; Peter Savolainen; Ben Sacks; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; mtDNA; domestication; Y-chromosome; SNP; ASY; dog; dingo;

    Abstract : The domestic dog was probably the first domesticated animal, and the only one to spread to all continents in ancient times. The dog is one of the most phenotypically diverse animals, a result of human selection throughout dog history. READ MORE

  6. 4. Regulation of Human Mitochondrial DNA Replication and Transcription

    Author : Majda Mehmedovic; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; transcription; TFAM;

    Abstract : Mitochondria are organelles in eukaryotic cells, which through oxidative phosphorylation (OXPHOS) produce most of the ATP used to drive cellular processes. The organelle contains its own genetic material, mitochondrial DNA (mtDNA), which encodes 13 key components of the OXPHOS machinery. READ MORE

  7. 5. Analysis of domestic dog mitochondrial DNA sequence variation for forensic investigations

    Author : Helen Angleby; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biotechnology; forensics; mtDNA; control region; hair; domestic dog; breed; Bioteknik; Bioengineering; Bioteknik;

    Abstract : The first method for DNA analysis in forensics was presented in 1985. Since then, the introduction of the polymerase chain reaction (PCR) has rendered possible the analysis of small amounts of DNA and automated sequencing and fragment analysis techniques have facilitated the analyses. READ MORE