Search for dissertations about: "mucosal adjuvant"

Showing result 21 - 25 of 32 swedish dissertations containing the words mucosal adjuvant.

  2. 21. Mechanistic studies of the adjuvant effects of CTA1-DD and the native cholera toxin: Impact of cell targeting and tissue localization

    Author : Johan Mattsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vaccines; adjuvants; cholera toxin; germinal center; CTA1-DD; follicular dendritic cells; denritic cells; Th1; Th2; Th17; complement;

    Abstract : Vaccines are the most effective means of preventing infectious diseases and improving global health. However, few vaccines have successfully been developed for protection at mucosal surfaces where most pathogens gain access. READ MORE

  4. 22. PROTEIN VACCINE AGAINST NEONATAL GROUP B STREPTOCOCCAL INFECTION Immunization experiments in animals and a serological study in humans

    Author : Charlotte U Larsson; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; mycology; bacteriology; Microbiology; virologi; mykologi; neonatal infection; human antibody; intranasal; vaccine; cholera toxin B subunit; Rib; α; Group B streptococcus; surface protein; Mikrobiologi; virology;

    Abstract : Infection with group B streptococcus (GBS), an encapsulated bacterium, is an important cause of neonatal morbidity and mortality. Capsular polysaccharides and cell surface proteins of GBS are candidate antigens for development of a human GBS vaccine. Proteins have many advantages as vaccine antigens. READ MORE

  5. 23. Improving the immunogenicity of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nearly 30 years have passed since the start of the global HIV epidemic and we are still unable to control the spread of the virus. HIV predominately infects cells crucial for the function of the immune system, integrates into the host genome and demonstrates a huge genetic variability, and the use of therapeutic antiretroviral drugs can restrain but not clear the infection. READ MORE

  6. 24. Dendritic cell responses to apoptotic cells : is there life after death?

    Author : Ulrika Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dendritic cells (DC) are antigen-presenting cells that are crucial for the induction of immune responses to pathogens and for the maintenance of self-tolerance. DCs efficiently capture and process material from their local environment, including invading pathogens and dying cells of the host, and present the material to the adaptive immune response. READ MORE

  7. 25. A mouse model for direct evaluation of cholera vaccines

    Author : Erik Nygren; Göteborgs universitet; []
    Keywords : Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Abstract : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). READ MORE