Search for dissertations about: "mucosal adjuvant"

Showing result 6 - 10 of 32 swedish dissertations containing the words mucosal adjuvant.

  2. 6. Starch Microparticles as an Oral Vaccine Adjuvant with Emphasis on the Differentiation of the Immune Response

    Author : Linda Stertman; Ingvar Sjöholm; Kjell-Olov Grönvik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Vaccine adjuvant; Microparticles; Oral immunisation; Th1 Th2 differentiation; Mucosal immune response; Uptake; M cell; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Polyacryl starch microparticles have been developed as an oral vaccine adjuvant capable of inducing strong local and systemic immune responses in mice. In this thesis, the starch microparticles were studied in order to increase basic understanding of their function. READ MORE

  4. 7. Studies on the immuno-modulating properties of the cholera toxin A1-based fusion protein CTA1-DD

    Author : Anna Eriksson; Göteborgs universitet; []
    Keywords : adjuvant; cholera toxin; mucosa; targeting; B cell; immuno-modulation; vaccine;

    Abstract : The present work was aimed at exploring the immuno-modulating properties of the novel cholera toxin (CT)-based vaccine adjuvant CTA1-DD, which combines the full enzymatic activity of the A1 subunit of CT with B cell targeting. We have studied the efficacy of the CTA1-DD adjuvant to enhance immune responses in mice after nasal administration. READ MORE

  5. 8. Mast cells: bad enemies or good friends? : A study of the effects of IgG immune complexes on mast cell biology

    Author : Lisa M Larsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mast cell; Fc receptor; Apoptosis; Immune complex; Adjuvant; CTA1-DD.;

    Abstract : Mast cells are classically defined as bad enemies to human health due to their critical involvement in IgE-dependent allergy by virtue of the expression of the high affinity IgE receptor, FcgammaRI, on these cells. However, mouse mast cells also express FcgammaRIIB and FcgammaRIIIA, two receptors that bind IgG especially in the form of IgG immune complexes. READ MORE

  6. 9. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes

    Author : Sara Tengvall; Göteborgs universitet; []
    Keywords : female genital tract immunity; genital herpes; mucosal adjuvant; TLR; MyD88; CpG ODN;

    Abstract : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. READ MORE

  7. 10. Mucosal adjuvants and their mode of action in the female genital tract

    Author : Madelene Lindqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; mucosal adjuvants; genital tract; vaccine; HSV-2; mouse; alpha-galactosylceramid; CpG ODN; proteoliposome-derived cochleate; inflammation; bioinformatics;

    Abstract : Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is caused by herpes simplex virus type 2 with over 536 million people infected world-wide. READ MORE