Search for dissertations about: "mucosal drug delivery"

Found 4 swedish dissertations containing the words mucosal drug delivery.

  2. 1. Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

    Author : Helene Hägerström; Katarina Edsman; Arne Brodin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gel; rheology; mucoadhesion; mucosal drug delivery; in situ gel; gellan gum; Carbopol; tensile strength; nasal mucosa; intranasal administration; dielectric spectroscopy; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. READ MORE

  4. 2. Controlled Release Gel Formulations for Mucosal Drug Delivery

    Author : Mattias Paulsson; David Attwood; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Galenisk farmaci; Pharmaceutics;

    Abstract : Drug delivery to nasal or ocular mucosa for either local or systemic action faces many obstacles – these routes are protected by effective mechanisms. Gel formulations with suitable rheological and mucoadhesive properties increase the contact time at the site of absorption. READ MORE

  5. 3. The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery : Method Development and Applications Using Different Formulations

    Author : Karin Östh; Anna-Lena Ungell; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. READ MORE

  6. 4. Local pharmacological treatment of inner ear disorders

    Author : Cecilia Engmér Berglin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hearing disorders are among the top 10 in terms of burden of disease in middle- and high-income countries, affecting 250 million people worldwide. During the last few decades researchers have made significant advances in understanding the basic mechanisms and molecular biology of inner ear diseases. READ MORE