Search for dissertations about: "mucosal vaccination"

Showing result 16 - 20 of 33 swedish dissertations containing the words mucosal vaccination.

  2. 16. Plant-produced STI vaccine antigens with special emphasis on HIV-1 p24

    Author : Ingrid Lindh; Åke Strid; Sören Andersson; Edward Rybicki; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant-based vaccines; Arabidopsis thaliana; HIV-1; p24; GALT; mucosal immunity; Chlamydia trachomatis; MOMP; Daucus carota; Chemistry; Kemi; Chemistry; Kemi;

    Abstract : Objective: To establish stable transgenic non-toxic plants as a platform for plant-based vaccine production as well as potential oral delivery system of vaccine antigens for sexually transmitted infections (STIs). The concept is to immunize the mucosal immune system present in the gut-associated lymphoid tissues (GALT). READ MORE

  4. 17. Mucosal and systemic immune responses in HIV-1 exposed uninfected individuals

    Author : Klara Hasselrot; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human immunodeficiency virus (HIV) is an infectious agent that, for 26 years, has evaded vigorous attempts to invent either a cure or preventive agent. Even though the immunological understanding of HIV s pathogenesis has greatly improved, most knowledge has been gained from studies of systemic compartments but less from the mucosal environment, where the majority of all infections occur. READ MORE

  5. 18. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action

    Author : Manuela Terrinoni; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vaccine development; plasmid maintenance; Gram-negative bacteria; ; essential genes; complementation; Cholera Toxin; adjuvanticity; NF-kB; mmCT; Gram-negative bacteria;

    Abstract : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. READ MORE

  6. 19. Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses

    Author : Tanvir Ahmed; Göteborgs universitet; []
    Keywords : Vibrio cholerae; ETEC; oral vaccine; CS6; CFA I; Lewis blood group; zinc; breast feeding; T cell; B cell;

    Abstract : Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses Abstract Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) together account for the majority of bacterial causes of acute dehydrating diarrhea in children in Bangladesh. Vaccines should be considered as an important public health tool for prevention of these diarrheal diseases. READ MORE

  7. 20. Studying the influence of the physicochemical properties of lipid nanoparticles for mucosal vaccine delivery

    Author : Karin Norling; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; nanoparticles; CTA1-DD; liposomes; dendritic cells; lipodisks; antigen presentation; flow cytometry; vaccine carriers; TIRF microscopy;

    Abstract : Lipid-based nanoparticles have attracted attention as promising pharmaceutical carriers. Reports of them having inherent adjuvant properties make them particularly interesting as vaccine vectors; however, the physicochemical profile of an ideal nanoparticle for mucosal vaccine delivery remains unknown. READ MORE