Search for dissertations about: "mucosal vaccine"

Showing result 1 - 5 of 54 swedish dissertations containing the words mucosal vaccine.

2. 1. Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection

   Author : Valentina Bernasconi; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucosal vaccination; Influenza A virus; CTA1-DD; Nanoparticle; Targeted adjuvant; Nasal immunization; Oral immunization; Neonatal vaccine; Universal vaccine;

   Abstract : Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. READ MORE

4. 2. Mucosal adjuvants and their mode of action in the female genital tract

   Author : Madelene Lindqvist; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; mucosal adjuvants; genital tract; vaccine; HSV-2; mouse; alpha-galactosylceramid; CpG ODN; proteoliposome-derived cochleate; inflammation; bioinformatics;

   Abstract : Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is caused by herpes simplex virus type 2 with over 536 million people infected world-wide. READ MORE

5. 3. Gastrointestinal norovirus infections and the development of the next generation of mucosal vaccines

   Author : Inga Rimkute; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human norovirus; gastrointestinal infection; mucosal vaccine; subcomponent vaccine; human intestinal enteroids; histo-blood group antigens; lipidomics; glycoproteomics; glycosphingolipids;

   Abstract : Human norovirus (HuNoV) is the causative agent of the winter vomiting disease and the leading cause of outbreaks of gastrointestinal infections across all settings and age groups in the world. The virus is highly contagious making outbreaks difficult or often impossible to control and having a high impact on societal costs and resources. READ MORE

6. 4. Development of a New Oral Vaccine against Diphtheria and the Study of its Immunogenicity in Mouse and Man

   Author : Niclas Rydell; Ingvar Sjöholm; Sveinbjörn Gizurarson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral vaccination; mucosal vaccination; diphtheria; biodegradable; microparticles; starch; CRM197; adjuvant; vaccine; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : Most pathogens enter the body via mucosal surfaces. In contrast to parenterally administered vaccination, mucosal vaccination has the advantage of eliciting both a systemic and a local mucosal immune response. An oral biodegradable adjuvant with these features would have great potential. READ MORE

7. 5. Liposomes for mucosal vaccine delivery: physicochemical characterization and biological application

   Author : Karin Norling; Chalmers tekniska högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanoparticles; vaccine carriers; antigen presentation; dendritic cells; surface plasmon resonance; flow cytometry; liposomes; cellular uptake; fluorescence microscopy; influenza;

   Abstract : Liposomes are attractive vaccine carriers due to their potential to act as adjuvants, and to the fact that their composition and characteristics are virtually endlessly customizable. However, the precise physicochemical profile of an ideal carrier liposome for mucosal vaccines is still widely unknown, and how different properties affect key steps in the acquisition of protective immunity remains to be elucidated. READ MORE