Search for dissertations about: "mucus gel layer"

Showing result 1 - 5 of 14 swedish dissertations containing the words mucus gel layer.

  2. 1. Gastrointestinal mucosal protective mechanisms : Mudolatory effects of Heliobacter pyroli on the gastric mucus gel barrier and mucosal blood flow in vivo

    Author : Christer Atuma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; mucus gel layer; mucosal blood flow; mucus thickness; chronic infection; rat; platelet activating factor; mast cell; nitric oxide; nitric oxide synthase; ketotifen; intra-vital microscopy; microelectrode; laser-Doppler flowmetry; L-NNA; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Abstract : The gastrointestinal mucus gel layer and blood flow are two important mechanisms for protection at the pre-epithelial and sub-epithelial levels, respectively. Helicobacter pylori might circumvent these mechanisms and elicit a chronic inflammatory response with consequent ulcers in the stomach and duodenum. READ MORE

  4. 2. Colonic mucus structure and processing

    Author : Elisabeth E. L. Nyström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucus; CLCA1; Goblet cell; Spdef;

    Abstract : The mucus layer covering the colonic epithelium creates a crucial first line of defense against the gut residing bacteria. Several lines of evidence suggest that a functional mucus layer is essential for health. For example, it is. suggested that ulcerative colitis is correlated with mucus layer defects. READ MORE

  5. 3. Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

    Author : Helene Hägerström; Katarina Edsman; Arne Brodin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gel; rheology; mucoadhesion; mucosal drug delivery; in situ gel; gellan gum; Carbopol; tensile strength; nasal mucosa; intranasal administration; dielectric spectroscopy; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. READ MORE

  6. 4. Nitrate, Nitrite and Nitric Oxide in Gastric Mucosal Defense

    Author : Joel Petersson; Lena Holm; Jon Lundberg; Mia Phillipson; Matthew Grisham; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dietary nitrate; mucus gel layer; mucosal blood flow; mucus thickness; laser-Doppler flowmetry; mucosal damage; intra-vital microscopy; mucosal permeability; Physiology; Fysiologi;

    Abstract : The human stomach normally contains high levels of bioactive nitric oxide (NO). This NO derives from salivary nitrate (NO3-) that is converted to nitrite (NO2-) by oral bacteria and thereafter non-enzymatically reduced in the acidic gastric lumen to NO. READ MORE

  7. 5. Helicobacter pylori and Gastric Protection Mechanisms : An in vivo Study in Mice and Rats

    Author : Johanna Henriksnäs; Lena Holm; Lars Engstrand; Erik Persson; Lars Fändriks; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; mucus gel layer; mucosal blood flow; mucus thickness; intra-vital microscopy; laser-Doppler flowmetry; pH-sensitive microelectrode; nitric oxide; Helicobacter pylori; bicarbonate secretion; mouse model; Fysiologi; Physiology; Fysiologi;

    Abstract : The stomach is frequently exposed to hazardous agents and to resist this harsh environment, several protective mechanisms exist. Of special interest is the gastric pathogen Helicobacter pylori which causes gastritis, ulcers and cancer but the mechanism leading to these diseases are still unclear. However it is very likely that H. READ MORE