Search for dissertations about: "mucus layer"

Showing result 16 - 20 of 44 swedish dissertations containing the words mucus layer.

2. 16. Microcirculation, Mucus and Microbiota in Inflammatory Bowel Disease

   Author : Olof Schreiber; Lena Holm; Mia Phillipson; Henrik Sjövall; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammatory bowel diseases; experimental colitis; DSS; TNBS; colonic mucosal blood flow; laser-doppler flowmetry; colonic mucus thickness; MUC2; colonic mucosal barrier function; iNOS; eNOS; probiotics; Lactobacilli; Lactobacillus reuteri; colonic microbiota; T-RFLP; bacterial translocation; intravital microscopy; P-selectin; leukocyte recruitment; platelet recruitment; Physiology; Fysiologi; Physiology; Fysiologi;

   Abstract : Inflammatory bowel diseases, (IBD), are a group of chronic disorders of the gastro-intestinal tract, and include Crohn’s disease (CD) and Ulcerative Colitis (UC). The pathogenesis is not known, but involves at least in part a loss of tolerance towards the commensal colonic microbiota. READ MORE

4. 17. Helicobacter spp. – host interaction in the mucus niche

   Author : Médea Padra; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter; mucin; glycosylation; adhesion;

   Abstract : Helicobacter pylori is the most common human gastric pathogen, colonizing half of the world's population. Helicobacter suis colonizes the stomach of 60-95% of pigs at slaughter age and it is the most prevalent non-Helicobacter pylori Helicobacter species found in the human stomach causing severe gastric disorders. READ MORE

5. 18. Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

   Author : Helene Hägerström; Katarina Edsman; Arne Brodin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gel; rheology; mucoadhesion; mucosal drug delivery; in situ gel; gellan gum; Carbopol; tensile strength; nasal mucosa; intranasal administration; dielectric spectroscopy; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. READ MORE

6. 19. Mucins, Cystic Fibrosis and PDZ protein interactions

   Author : Emily Malmberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

   Abstract : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. READ MORE

7. 20. Assembly and proteolytic cleavages of gel-forming mucins

   Author : Martin Lidell; Göteborgs universitet; []
   Keywords : mucins; MUC2; MUC5AC; dimer; trimer; cleavage; Entamoeba histolytica; cysteine protease;

   Abstract : Gel-forming mucins are large glycoproteins constituting the main structural component of themucus layer protecting epithelial surfaces of the body. This thesis aims to a deeper understandingof how gel-forming mucins are synthesized and assembled, and how they may interact with othermolecules. READ MORE