Search for dissertations about: "multicenter study"
Showing result 1 - 5 of 136 swedish dissertations containing the words multicenter study.
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1. Impact of disease and treatment on body weight and eating in patients with head and neck cancer : experiences from a multicenter study
Abstract : Background Nutritional deterioration in patients with head and neck cancer (HNC) has a multifactorial etiology mainly associated with tumor and treatment related factors. The objective of the present thesis was to investigate the impact of the disease and treatment on body weight and eating in patients with HNC treated with radiation therapy (RT) as the single modality treatment or as preoperative RT by analyzing body weight and body mass index (BMI) over time, predictive factors for weight loss and BMI, weight loss and BMI as prognostic factors for survival, and by studying the patients’ own experience of food and eating. READ MORE
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2. Surgical and neurological adverse effects of epilepsy surgery
Abstract : The aim of this thesis was to study surgical and neurological complications of preoperative invasive investigations and epilepsy surgery procedures (Papers I-II) and seizure worsening after epilepsy surgery (Paper III). A further aim was to improve reporting of adverse effects related to invasive investigations and epilepsy surgery by proposing and evaluating an evidence-based protocol for monitoring complications (Paper IV). READ MORE
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3. Idiopathic polyneuropathy : a pathogenetic study
Abstract : Polyneuropathy (PNP) stands for dysfunction in the peripheral nerves. The classical clinical manifestations of PNP are distal, symmetric sensory symptoms, such as numbness and pain, as well as distal weakness in a sock- and glove pattern. For most patients with PNP, the progression rate is slow and the degree of impairment is limited. READ MORE
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4. Health-related Quality of Life in Head and Neck Cancer. A Five-year Prospective Multicenter Study
Abstract : The aim of this prospective longitudinal multicenter study was to evaluate the health-related quality of life (HRQL) in patients with head and neck cancer at diagnosis, after one and five years in relation to tumour location, stage, sub site, treatment modality, gender and age. The first part of the study, lasting for one year, consisted of 357 patients (mean age 63 years; 72% males) that were included between 1993 and 1995. READ MORE
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5. Growth hormone responsiveness in children : results from Swedish multicenter clinical trials of growth hormone treatment
Abstract : The general aims of the thesis were to study GH responsiveness by estimation of pharmacokinetics and bioavailability of injected recombinant human GH (rhGH), of growth response as gain in heightSDS during childhood and puberty, and IGF-I response as change in circulating IGF-ISDS and IGFBP3SDS. Methods Short children were recruited during 1988–1999 into two national randomized multicentre clinical trials on growth until adult height. READ MORE