Search for dissertations about: "multidrug-resistance gene"

Showing result 1 - 5 of 28 swedish dissertations containing the words multidrug-resistance gene.

  2. 1. Experimental studies on multidrug resistance in human leukaemia : role of cellular heterogeneity for daunorubicin kinetics

    Author : Eva Knaust; Curt Peterson; Anna Porwit-MacDonald; Astrid Gruber; Christer Paul; Linköpings universitet; []
    Keywords : Acute myeloid leukaemia; heterogeneity; multidrug resistance. transport kinetics flow cytometry; gene expression; mdr1; mrp; lrp; apoptosis. bcl-2; p53; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myeloid leukaemia (AML) and still the majority of the patients die from their disease. Drug resistance 1s multifactorial, the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (Pgp). READ MORE

  4. 2. Plasmodium falciparum drug transporter genes in emerging malaria multidrug resistance

    Author : Maria Isabel Mendes Veiga; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria is caused by an intracellular protozoan parasite of the genus Plasmodium. The use of chemotherapy, the foremost tool available for the control of the disease, has been challenged in the last decades by the development and spread of drug resistance among malaria parasites. READ MORE

  5. 3. Klebsiella pneumoniae and Escherichia coli : multidrug-resistance and different aspects of invasive infections

    Author : Malin Vading; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Klebsiella pneumoniae and Escherichia coli are pathogens belonging to the Enterobacteriaceae family. They can cause infections ranging from uncomplicated urinary tract infection to severe bloodstream infection (BSI). READ MORE

  6. 4. Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines

    Author : Kerstin Jönsson Videsäter; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multidrug resistance; cross-resistance profile; ATP-bioluminescence assay; pglycoprotein; MRP1; selenium; thioredoxin reductase; glutathione reductase.;

    Abstract : Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of multidrug resistance and to establish in vitro methods to characterize the resistant tumor cell phenotype. READ MORE

  7. 5. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

    Author : Eva Knaust; Linköpings universitet; []
    Keywords : Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. READ MORE