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Showing result 1 - 5 of 123 swedish dissertations matching the above criteria.

2. 1. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

   Author : Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

   Abstract : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. READ MORE

4. 2. Epidemiology, diagnostics and treatment of non-melanoma skin cancers

   Author : Oscar Zaar; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; non-melanoma skin cancer; basal cell carcinoma; merkel cell carcinoma; Bowen’s disease; imaging mass spectrometry; lipidomics; photodynamic therapy;

   Abstract : Skin cancer, including malignant melanoma and non-melanoma skin cancer (NMSC), is a growing problem due to the increasing incidence in Sweden and in other Caucasian populations. NMSCs are diagnosed as often as all other cancers combined and include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), precursors to SCC such as Bowen’s disease (BD) and actinic keratosis (AK), as well as several rare skin cancers including Merkel cell carcinoma (MCC). READ MORE

5. 3. Tumors associated with Hereditary Nonpolyposis Colorectal Cancer: Defective Mismatch Repair and Familial Risk of Cancer

   Author : Kajsa Ericson Lindquist; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Multiple Tumors; Hereditary Nonpolyposis Colorectal Cancer; Cytology; Cohort study; Population based; Familial Risk of Cancer; Immunohistochemistry; MSH2; MSH6; MLH1; Microsatellite Instability; Soft Tissue Sarcomas; Cancer of the Upper Urinary Tract; Cancer of the Small Intestine; Colorectal Cancer;

   Abstract : Inactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated sequences, and 90% of MSI tumors show loss of immunohistochemical expression for the MMR protein affected. READ MORE

6. 4. Cancer of unknown primary: searching for the etiological clues. A population-based epidemiological study in Sweden

   Author : Xiaochen Shu; Allmänmedicin och klinisk epidemiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer of unknown primary; causes of death; familial risk; immigrant; incidence; multiple malignancies; risk factor; squamous cell carcinoma; standardizedincidence ratio; survival;

   Abstract : This thesis aimed to search for etiological clues about cancer of unknown primary(CUP) by gathering novel information. The Swedish national registries were used and CUP cases were identified according to the seventh revision of the International Classification of Diseases. READ MORE

7. 5. Hepatitis C virus infection : a nationwide study of associated morbidity and mortality

   Author : Ann-Sofi Duberg; Erik Bäck; Karl Ekdahl; Rolf Hultcrantz; Anders Blaxhult; Johan Carlson; Örebro universitet; []
   Keywords : HCV; hepatitis C; epidemiology; non-Hodgkin s lymphoma; NHL; multiple myeloma; primary liver cancer; HCC; mortality; inpatient care; hospitalization; MEDICINE; MEDICIN; Infektionssjukdomar; Infectious Diseases; Epidemiology; Epidemiologi; Medicin; Medicine;

   Abstract : The hepatitis C virus (HCV) was characterised in 1989. HCV was transmitted through transfusion of blood/blood products, but injection drug use is now the most common route of transmission. READ MORE