Search for dissertations about: "multiple cancers"
Showing result 11 - 15 of 123 swedish dissertations containing the words multiple cancers.
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11. Molecular characterization of FOX factors and Wnt signalling interplay in human cancers
Abstract : Wnt/β-catenin signalling, also referred to as canonical Wnt signalling, is a critical regulator of tissue homeostasis and of the differentiation of cells during development. The outcome of canonical Wnt pathway activity is defined by the regulation of target gene transcription, which ultimately determines cell identity and proliferation. READ MORE
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12. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
Abstract : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. READ MORE
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13. Malignant melanoma-Risk factors and the CDKN2A mutation in relation to phenotypes and other cancers
Abstract : Background: Cutaneous malignant melanoma (CMM) is an increasingly common cancer in fair-skinned people. The purpose of this thesis was to study high-risk patients with multiple tumours including a CMM, high-risk families with the unique Swedish germline mutation in CDKN2A(113insArg), as well as study risk factors for CMM in women. READ MORE
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14. PET and MRI of Prostate Cancer
Abstract : Prostate cancer (PCa) is the most common non-skin malignancy of men in developed countries. In spite of treatment with curative intent up to 30-40% of patients have disease recurrence after treatment, resulting from any combination of lymphatic, hematogenous, or contiguous local spread. READ MORE
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15. Proteomics and metabolomics in biological and medical applications
Abstract : Biological processes in living organisms consist of a vast number of different molecular networks and interactions, which are complex and often hidden from our understanding. This work is focused on recovery of such details for two quite distant examples: acclimation to extreme freezing tolerance in Siberian spruce (Picea obovata) and detection of proteins associated with prostate cancer. READ MORE