Search for dissertations about: "multiple myeloma genetic"

Showing result 1 - 5 of 17 swedish dissertations containing the words multiple myeloma genetic.

  2. 1. Genetic Predisposition to Sporadic and Familial Multiple Myeloma

    Author : Britt-Marie Halvarsson; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; genetics; inherited predisposition; familial multiple myeloma; GWAS; polygenic risk score;

    Abstract : Multiple Myeloma (MM) is the second most common hematological malignancy. It is defined by an uncontrolled growth of plasma cells, usually in the bone marrow. Clinically it is complicated by hypercalcemia, renal failure, anaemia, and bone pain. READ MORE

  4. 2. Genetic analyses of multiple myeloma and related plasma cell dyscrasias

    Author : Therese Nilsson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetik; cytogenetik; cytogenetics; Genetics; FISH; cytogenetic; multiple myeloma; MGUS;

    Abstract : Acquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias. READ MORE

  5. 3. Genetic predisposition for Multiple Myeloma. Identification and functional characterization of risk variants

    Author : Laura Duran Lozano; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; multiple myeloma; CRISPR Cas9; cancer genetics; functional characterization; Germline variants;

    Abstract : Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph. READ MORE

  6. 4. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Author : Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Keywords : Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Abstract : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. READ MORE

  7. 5. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy

    Author : Mohammad Alzrigat; Helena Jernberg-Wiklund; Fredrik Öberg; Kristina Drott; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple Myeloma; Epigenetics; Polycomb; PRC2; PRC1; EZH2; BMI-1; UNC1999; PTC-209; Epigenetic Therapy; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Abstract : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. READ MORE