Advanced search

Showing result 1 - 5 of 131 swedish dissertations matching the above criteria.

  2. 1. Regulation of apoptosis in human multiple myeloma

    Author : Helena Spets; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; apoptosis; multiple myeloma; IL-6; Bcl-2; Fas; dexamethasone; IGF-I; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Multiple myeloma (MM) is a clonal expansion of malignant plasmablasts-plasma cells in the bone marrow. MM is slowly proliferating and an increased resistance to apoptosis may be crucial for the tumor progression. READ MORE

  4. 2. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Author : Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Keywords : Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Abstract : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. READ MORE

  5. 3. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Author : Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Abstract : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. READ MORE

  6. 4. Life, death ant the role of IGF-I in human multiple myeloma

    Author : Patrik Georgii-Hemming; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Multiple Myeloma; IGF-I; apoptosis; Fas; glucocorticoids; somatostatin; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Multiple myeloma (MM) is a clonal expansion of malignant cells with a plasmablast- plasma cell morphology in the bone marrow. It is a fatal disease with a median survival of 2-3 years after start of conventional therapy. READ MORE

  7. 5. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling

    Author : Thomas Strömberg; Helena Jernberg Wiklund; Kenneth Nilsson; Anders Waage; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Multiple myeloma; IGF-IR; apoptosis; somatostatin; octreotide; dexamethasone; GSK-3; mTOR; rapamycin; RTK inhibitor; Patologi; Pathology; Patologi;

    Abstract : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. READ MORE