Search for dissertations about: "multiple sclerosis , genetic"

Showing result 1 - 5 of 94 swedish dissertations containing the words multiple sclerosis , genetic.

2. 1. Genetic Analyses of Multiple Sclerosis and Systemic Lupus Erythematosus : From Single Markers to Genome-Wide Data

   Author : Johanna K Sandling; Ann-Christine Syvänen; Lovisa Lovmar; Joseph Terwilliger; Javier Martín Ibáñez; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; Multiple Sclerosis; Association study; Type I interferon system; Single nucleotide polymorphism; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

   Abstract : In autoimmune diseases an individual’s immune system becomes targeted at the body’s own healthy cells. The aim of this thesis was to identify genetic risk factors for the two autoimmune diseases multiple sclerosis (MS) and systemic lupus erythematosus (SLE). READ MORE

4. 2. Modeling genetic susceptibility to multiple sclerosis

   Author : Helga Westerlind; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The main aim of this thesis was to investigate genetic and environmental factors and their role in the etiology of Multiple Sclerosis (MS) by using comprehensive registry data or novel computationally intense methods. To date, over 100 genes associated with MS have been identified, but how they interact in the risk for the disease is not yet fully understood. READ MORE

5. 3. Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis

   Author : Hai-Tao Yang; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Collagen induced arthritis CIA ; Experimental allergic encephalomyelities EAE ; Multiple sclerosis MS ; Quantitative trait loci QTL ; Rheumatoid arthritis RA ; Linkage analysis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. READ MORE

6. 4. Genetic mapping and association analysis in multiple sclerosis

   Author : Eva Åkesson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Multiple sclerosis; genetic; linkage; association; susceptibility;

   Abstract : Multiple sclerosis (MS) is a chronic neurological disease. Epidemiological studies have shown evidence for both environmental and genetic involvement of the disease. READ MORE

7. 5. Multiple Sclerosis: Studies of the Interferon system and search for infectious agents

   Author : My Bergkvist; Lund Neurologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; Axon and myelin damage; IgG; Virus; Interferon; Multiple Sclerosis; Genetic linkage;

   Abstract : Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. READ MORE