Search for dissertations about: "multiple sclerosis in mice"

Showing result 16 - 20 of 48 swedish dissertations containing the words multiple sclerosis in mice.

  2. 16. The role of B cells and Th2 cytokines in physiological and pathological inflammation

    Author : Lars Svensson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammation Th2 Cytokines B cells antibodies mice estrogen; transplantation; Immunology; serology; Immunologi; serologi;

    Abstract : The CD4+ T cells have an important role in inflammation. Based on the local cytokine milieu, these cells can differentiate into either a Th1 population promoting cellular immunity or Th2 population involved in humoral immunity. READ MORE

  4. 17. Multiple roles of HMGB1 in clinical and experimental arthritides

    Author : Hanna Schierbeck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inflammation can be infectious and/or sterile depending on the initiating event. The proinflammatory mediator High mobility group box protein 1 (HMGB1) is a nuclear protein released from cells during both sterile and infectious inflammation and once extracellular, initates and potentiates inflammation by inducing cytokine production and by recruiting inflammatory cells. READ MORE

  5. 18. Myeloid cells in autoimmune diseases

    Author : Muhammad Sohel Mia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple Sclerosis (MS) and Type 1 Diabetes (T1D) are autoimmune diseases caused by dysregulation of the immune system. Monocytes/macrophages are myeloid cells that play a pivotal role in both induction and resolution of these diseases depending on the stage and microenvironment of disease course. READ MORE

  6. 19. Reduced ROS production triggers arthritis / The role of T cells in arthritis pathogenesis

    Author : Jens Holmberg; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Spleen and lymph nodes Inflammation Reactive oxygen species T cells MHC; serology; Immunology; Immunologi; serologi;

    Abstract : The aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. READ MORE

  7. 20. Gene regulatory mechanisms in the oligodendrocyte lineage in development and disease

    Author : Mandy Meijer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They contribute to the neuronal network through the insulation of neuronal axons, facilitating communication between neurons and providing metabolic support. READ MORE