Search for dissertations about: "multiplex immunofluorescence"

Showing result 1 - 5 of 12 swedish dissertations containing the words multiplex immunofluorescence.

  2. 1. Generation and characterization of antibodies for proteomics research

    Author : Karin Larsson; Sophia Hober; John McCafferty; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody; antibody validation; immunohistochemistry; immunofluorescence; tissue microarray; Western blot; epitope mapping; antigen design; Bioengineering; Bioteknik;

    Abstract : Specific antibodies are invaluable tools for proteomics research. The availability of thoroughly validated antibodies will help to improve our understanding of protein expression, localization and function; fundamental processes and features of all living organisms. READ MORE

  4. 2. Spatial immune analyses in clinical cancer tissue

    Author : Max Backman; Patrick Micke; Fredrik Pontén; Johan Botling; Kurt Schalper; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune landscape; non-small cell lung cancer; immune cells; multiplex immunofluorescence; spatial analysis; Medicinsk vetenskap; Medical Science;

    Abstract : Cancer is a leading cause of premature death and lung cancer is the deadliest cancer type, with non-small cell lung cancer (NSCLC) representing 85% of lung cancer cases. Despite promising development in cancer treatment in recent decades, overall prognosis is poor. READ MORE

  5. 3. Diagnostic methods for bacterial etiology in adult community-acquired pneumonia

    Author : Kristoffer Strålin; Åke Örtqvist; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The etiologic agent is often unidentified in patients with community-acquired pneumonia (CAP). Development of new diagnostic methods has been encouraged. We aimed to develop a multiplex PCR (mPCR) assay for common bacterial pathogens and evaluate the diagnostic usefulness of this assay and of respiratory culture in CAP. READ MORE

  6. 4. The role of ABC transporters and inflammation in drug-resistant epilepsy

    Author : Lora Deuitch Weidner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis explores two pathologies thought to be related to drug resistance in epilepsy that may themselves be causally related: 1) overexpression of drug transporters in capillaries and 2) inflammation. With regard to the first hypothesis, overexpression of the ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), at the blood-brain barrier are thought to contribute to drug resistance in epilepsy. READ MORE

  7. 5. Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses

    Author : Azar Rezapour; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal cancer; Tumor infiltrating T cell; MxA; Interferon type I; CD39; CD103; PD-1; cytokines; response to the treatment;

    Abstract : Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies of these interactions to pave for more effective therapeutic strategies. READ MORE