Search for dissertations about: "multivariate design"

Showing result 1 - 5 of 117 swedish dissertations containing the words multivariate design.

  1. 1. Multivariate design of molecular docking experiments An investigation of protein-ligand interactions

    University dissertation from Umeå : Umeå universitet. Kemiska institutionen

    Author : David Andersson; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular docking; chemometrics; multivariate analysis; principal component analysis; PCA; design of experiments; DoE; partial least-square projections to latent structures; PLS; scoring functions; ligand-binding cavity; major histocompatibility complex; MHC; glycopeptide; T-cell.; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; läkemedelskemi; läkemedelskemi;

    Abstract : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. READ MORE

  2. 2. Multivariate Synergies in Pharmaceutical Roll Compaction The quality influence of raw materials and process parameters by design of experiments

    University dissertation from Umeå : Umeå University

    Author : Nabil Souihi; Umeå universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

    Abstract : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. READ MORE

  3. 3. Multivariate methods in tablet formulation

    University dissertation from Umeå : Kemi

    Author : Jon Gabrielsson; Umeå universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; PCA; statistical experimental design; multivariate design; PLS; excipients; direct compression; tablet formulation; robustness testing; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes the application of multivariate methods in a novel approach to the formulation of tablets for direct compression. It begins with a brief historical review, followed by a basic introduction to key aspects of tablet formulation and multivariate data analysis. READ MORE

  4. 4. Aspects on probabilistic approach to design From uncertainties in pre-investigation to final design

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Anders Prästings; KTH.; [2016]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reliability-based design; Geotechnical design; Geotechnical structures; Sheet-pile wall; Characterization of uncertainties; Geotechnical investigations;

    Abstract : Geotechnical engineering is strongly associated with large uncertainties. Exploring a medium (soil) that is almost entirely and completely hidden from us is no easy task. Investigations can be made only at discrete points, and the majority of a specific soil volume is never tested. READ MORE

  5. 5. Metoder för informationsoptimering vid organisk syntes

    University dissertation from Umeå : Umeå universitet

    Author : Åke Nordahl; Umeå universitet.; [1990]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carboxamides; Carboxylic acids; Complex reducing agents CRA ; Experimental design; Lewis acids; Multivariate analysis; Multivariate design; Order of introduction; Principal component analysis PCA ; Principal component multiple regression PCMR ; Principal properties; Screening;

    Abstract : .... READ MORE