Search for dissertations about: "mutagen exposure"

Found 3 swedish dissertations containing the words mutagen exposure.

  2. 1. Chromosome aberrations and environmental exposures in acute leukemia

    Author : Ragnhild Rosengren Lindquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute leukemia; chromosome 3; chromosome 8; fragile site; occupational exposure; mutagen exposure; case-control study; trisomy; benzene; organic solvent; petroleum; epidemiology; environmental carcinogens; painter; driver;

    Abstract : The aims of this thesis are to evaluate the role of environmental exposures, especially professional exposure to organic solvents and petroleum products in the etiology of acute leukemia and to investigate if there is a correlation between the exposure to a specific leukemogen factor and a clonal chromosome aberration of the leukemic cells. Papers I and II present results of a case-control study of environmental exposures, in all occupations during life-time, medical treatments with medicines, chemotherapy and radiation, tobacco-use and the exposure to chemical compounds in private life in 120 patients with acute leukemia and of 120 controls, matched for age (+ 4 years), residence and sex. READ MORE

  4. 2. Methods for measurement of reactive metabolites as a basis for cancer risk assessment : Application to 1,3-butadiene and isoprene

    Author : Charlotta Fred; Margareta Törnqvist; Peter Farmer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi;

    Abstract : 1,3-Butadiene is a general air pollutant associated with combustion of organic matter and is also an extensively used monomer in polymer production. The cancer risk estimation of 1,3-butadiene is encumbered with large uncertainties. READ MORE

  5. 3. Somatic mutations in healthy cells and age-associated diseases

    Author : Hafdis Thorunn Helgadottir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aging is a complex process that affects all living organisms. As we age, the biological functions are affected, resulting in a decline of the tissue and possibly age-related diseases. Several environmental and genetic factors have been suggested to contribute to aging. READ MORE