Search for dissertations about: "mutant frequency"

Showing result 1 - 5 of 42 swedish dissertations containing the words mutant frequency.

  2. 1. Investigation of radiation-induced genetic and epigeneticeffects using cultured cells and Drosophila as experimental models: with focus on dose rate

    Author : Traimate Sangsuwan; Siamak Haghdoost; Ulrich Theopold; Stenerlöw Bo; David Berger; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Gamma radiation; low-dose-rate; MTH1; MYH; mutant frequency; Drosophila milanogaster; embryogenesis; mutation; molekylär biovetenskap; Molecular Bioscience;

    Abstract : .... READ MORE

  4. 2. Studies of mutant p53-targeting small molecules

    Author : Nicole Zache; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple cellular stresses, such as DNA damage, oncogene activation, hypoxia, and telomere erosion induce p53 protein levels leading to an array of biological responses, including cell cycle arrest and apoptosis. p53 exerts its function mainly through transcriptional regulation of specific target genes, but is also able to induce transcriptional-independent apoptosis. READ MORE

  5. 3. Studies on mutagenesis by ethylene oxide and styrene oxide in the hprt gene in human cells

    Author : Tatiana Bastlova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ethylene oxide; styrene; styrene-7; 8-oxide; human diploid fibroblasts; human T-lymphocytes; hprt mutation;

    Abstract : Environmental, occupational and life style-related exposures to mutagenic agents may contribute to cancer risk in humans. To prevent the potentially hazardous effects of such agents it is important to understand their mechanisms of action. READ MORE

  6. 4. Role of MTH1 and MYH proteins in genotoxic effects of radiation

    Author : Sara Shakeri Manesh; Siamak Haghdoost; William F. Morgan; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MTH1; MYH; gamma radiation; UV radiation; oxidative stress; low dose rate ionizing radiation; molekylärgenetik; Molecular Genetics;

    Abstract : Humans are constantly exposed to different types of radiations. It has been suggested that low dose and low dose rate of γ-radiation as well as ultra violet A (UVA) induce oxidative stress in cells that may promote mutations. READ MORE

  7. 5. HPRT mutational spectra and microsatellite DNA instability in HNPCC and lung cancer patients

    Author : Peter Hackman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Somatic gene mutation; mutational spectra; HPRT gene; lung cancer; smoking; hMLH1 gene; HNPCC; microsatellite instability; mismatch repair; T-cells;

    Abstract : The, general aims of this work have been to explore the use of microsatellite DNA length variation and mutational spectra of the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells as tools for a better understanding of human somatic mutagenesis in vivo. In particular (a) how inherited mismatch repair (MMR) deficiency may affect the stability of microsatellite DNA and the mutational spectrum at the HPRT locus, and (b) how the mutational spectrum at the HPRT locus is influenced by smoking, and by predisposition to lung cancer among never smokers. READ MORE