Search for dissertations about: "mutant"

Showing result 1 - 5 of 822 swedish dissertations containing the word mutant.

  1. 1. Mechanisms controlling striatal projection neurone generation, from patterning to early differentiation

    University dissertation from Håkan Toresson, Neurobiology, WNC BMC A11, S-221 84 LUND

    Author : Håkan Toresson; Lund University.; Lunds universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pbx; meis; sonic hedgehog; small eye; pax6; gsh2; gsh1; cerebral cortex; striatum; telencephalon; mutant; development; mouse; embryo; retinoic acid; Clinical biology; Klinisk biologi;

    Abstract : The striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. READ MORE

  2. 2. Genetic heterogeneity of hepatitis B and D viruses in chronic infection

    University dissertation from Yong Yuan Zhang, Dept. of Medical Microbiology, Section of Virology, University Hospital, MAS, 205 02 Malmo, SWEDEN

    Author : Yong Yuan Zhang; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteriology; Microbiology; phylogenetic analysis; mutant; mutation; genetic heterogeneity; HBV; HDV; hepatitis B; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : During the prolonged course of chronic viral infection there is a continuous reciprocal interaction between the host immune defence system and the viral immunogens, and viral genetic mutations capable of circumventing host immune defence could be selected for. Our observation of increasing prevalence of heterogeneity in the DNA sequence coding for the ‘a1 determinant of HBsAg in patients with presumed increasing length of chronic HBV infection is in agreement with the assumption of accumulation of presumed escape mutants. READ MORE

  3. 3. Studies of mutant p53-targeting small molecules

    University dissertation from Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Author : Nicole Zache; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Multiple cellular stresses, such as DNA damage, oncogene activation, hypoxia, and telomere erosion induce p53 protein levels leading to an array of biological responses, including cell cycle arrest and apoptosis. p53 exerts its function mainly through transcriptional regulation of specific target genes, but is also able to induce transcriptional-independent apoptosis. READ MORE

  4. 4. Pharmacological targeting of mutant p53 family members

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Nina Rökaeus; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The tumor suppressor p53 serves as a guardian of the genome and functions mainly as a transcription factor. In response to various stress signals p53 binds to specific DNA sequence motifs and regulates transcription of a large group of target genes involved in cellular processes such as cell cycle arrest, senescence and apoptosis. READ MORE

  5. 5. Cyanobacterial Hydrogen Metabolism - Uptake Hydrogenase and Hydrogen Production by Nitrogenase in Filamentous Cyanobacteria

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Pia Lindberg; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; cyanobacteria; biohydrogen; Nostoc; hydrogen production; hydrogen evolution; hydrogen metabolism; nitrogenase; hydrogenase; hydrogen; uptake hydrogenase; hupSL; hydrogen uptake mutant; uptake hydrogenase mutant; photobioreactor; hydrogenase accessory genes; hyp; transcription; RT-PCR; NtcA; mass spectrometry; heterocyst; Mikrobiologi; MEDICINE Microbiology; immunology; infectious diseases; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar;

    Abstract : Molecular hydrogen is a potential energy carrier for the future. Nitrogen-fixing cyanobacteria are a group of photosynthetic microorganisms with the inherent ability to produce molecular hydrogen via the enzyme complex nitrogenase. This hydrogen is not released, however, but is recaptured by the bacteria using an uptake hydrogenase. READ MORE