Search for dissertations about: "mutant"
Showing result 6 - 10 of 939 swedish dissertations containing the word mutant.
-
6. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis
Abstract : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. READ MORE
-
7. Directed Evolution of Glutathione Transferases Guided by Multivariate Data Analysis
Abstract : Evolution of enzymes with novel functional properties has gained much attention in recent years. Naturally evolved enzymes are adapted to work in living cells under physiological conditions, circumstances that are not always available for industrial processes calling for novel and better catalysts. READ MORE
-
8. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer
Abstract : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. READ MORE
-
9. Genes and Physiological Role of the Eukaryotic Nicotinamide Nucleotide Transhydrogenase
Abstract : Nicotinamide nucleotide transhydrogenase (NNT, EC 1.6.1. READ MORE
-
10. Advanced molecular tools for diagnostic analyses of RNA and antibodies in situ and in solution
Abstract : Advanced molecular diagnostics uses in vitro biological assays to detect nucleic acids or proteins even in low concentrations across samples, allowing for the identification of biomarkers, monitoring the course of the disease over time, and selection of appropriate therapy. In this thesis, I focus on development and early applications of several molecular tools of expected value in research, and eventually also clinically. READ MORE