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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.

  1. 1. The Role of IgM and Complement in Antibody Responses

    Author : Christian Rutemark; Birgitta Heyman; Claus Nielsen; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

    Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE

  2. 2. Anti-phosphorylcholine antibodies in cardiovascular disease

    Author : Roland Fiskesund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the industrialized countries and a growing concern for the developing world. The underlying cause of almost all CVD is atherosclerosis, a process that is characterized by a low-grade inflammation in the artery walls. READ MORE

  3. 3. Germinal centers - why and why not? : the humoral response in primary immunodeficiency

    Author : Carin Dahlberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : An efficient and regulated immune system is required for protection against pathogens. B cells are required for a humoral response. For a sustained humoral response against pathogens germinal center (GC) reactions are required. In the GC reaction, B cells with antigen-specific B cell receptors are selected and expanded. READ MORE

  4. 4. Pathogenetic factors of importance for the development and progression of rheumatoid arthritis

    Author : Heidi Kokkonen; Solbritt Rantapää-Dahlqvist; Dirkjan van Schaardenburg; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; cytokines; autoantibodies; isotypes; PTPN22; HLA-SE; reumatologi; rheumatology;

    Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation eventually leading to the destruction of cartilage and bone. The aetiopathogenesis is not completely understood, but previous studies have shown that the disease is multifactorial with genetic, environmental and hormonal factors involved. Immune cells, e. READ MORE

  5. 5. Regulation of the murine immunoglobulin GL gamma-1 and epsilon promoters

    Author : Lena Ström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The immune system takes advantage of different genetic alterations to amplify its diversity. First at early stages of B cell differentiation when the antigen (ag) receptors are assembled from different gene segments. READ MORE