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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.
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1. The Role of IgM and Complement in Antibody Responses
Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE
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2. Anti-phosphorylcholine antibodies in cardiovascular disease
Abstract : Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the industrialized countries and a growing concern for the developing world. The underlying cause of almost all CVD is atherosclerosis, a process that is characterized by a low-grade inflammation in the artery walls. READ MORE
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3. Germinal centers : why and why not? The humoral response in primary immunodeficiency
Abstract : An efficient and regulated immune system is required for protection against pathogens. B cells are required for a humoral response. For a sustained humoral response against pathogens germinal center (GC) reactions are required. In the GC reaction, B cells with antigen-specific B cell receptors are selected and expanded. READ MORE
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4. Pathogenetic factors of importance for the development and progression of rheumatoid arthritis
Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation eventually leading to the destruction of cartilage and bone. The aetiopathogenesis is not completely understood, but previous studies have shown that the disease is multifactorial with genetic, environmental and hormonal factors involved. Immune cells, e. READ MORE
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5. Regulation of the murine immunoglobulin GL gamma-1 and epsilon promoters
Abstract : The immune system takes advantage of different genetic alterations to amplify its diversity. First at early stages of B cell differentiation when the antigen (ag) receptors are assembled from different gene segments. READ MORE