Search for dissertations about: "mutation rate and antibiotic resistance"
Showing result 1 - 5 of 8 swedish dissertations containing the words mutation rate and antibiotic resistance.
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1. Evolution of Antibiotic Resistance
Abstract : The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. READ MORE
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2. Bacterial Resistance to Antimicrobial Peptides : Rates, Mechanisms and Fitness Effects
Abstract : The rapid emergence of bacterial resistance to antibiotics has necessitated the development of alternative treatment strategies. Antimicrobial peptides (AMPs) are important immune system components that kill microbes rapidly and have broad activity-spectra, making them promising leads for new pharmaceuticals. READ MORE
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3. Biological and Pharmacological Factor that Influence the Selection of Antibiotic Resistance
Abstract : Antibiotic treatment causes an ecological disturbance on the human microflora. Four commensal bacteria: E. coli, enterococci, a-streptococci and coagulase-negative staphylococci, from patients with extensive, high antibiotic usage were investigated with regard to resistance pattern and mutation frequency. READ MORE
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4. Dynamics and Mechanisms of Adaptive Evolution in Bacteria
Abstract : Determining the properties of mutations is fundamental to understanding the mechanisms of adaptive evolution. The major goal of this thesis is to investigate the mechanisms of bacterial adaptation to new environments using experimental evolution. READ MORE
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5. Statistical assessment of genomic variability in tumours and bacterial communities
Abstract : Current high-throughput DNA sequencing technologies have the ability to generate large amounts of high-resolution genomic data. The high dimensionality in combination with the substantial levels of technical errors and biological variability typically present in the data make, however, the analysis challenging. READ MORE