Search for dissertations about: "mutations"

Showing result 21 - 25 of 1635 swedish dissertations containing the word mutations.

  2. 21. On the evolutionary effects of linkage and deleterious mutations in small populations

    Author : Snæbjörn Pálsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Breeding systems; Daphnia pulex; deleterious mutations; linkage; neutral variation; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Genetics; genetik;

    Abstract : The aim of this thesis is to evaluate the effect of deleterious mutations and linkage on variation in neutral markers and fitness in small populations. The study is based on two main approaches, one by using computer simulations, the other by exploring genetic variation in a cyclical parthenogen, Daphnia pulex (Crustacea: Cladocera). READ MORE

  4. 22. Surviving the ratchet : Modelling deleterious mutations in asexual populations

    Author : Jonas Söderberg; Otto Berg; Laurence Loewe; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Theoretical biology; Population genetics; Stochastic modelling; Genome evolution; Muller s Ratchet; Genetics; Genetik; Organism biology; Organismbiologi; Biology; Biologi; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : One of the most unforgiving processes in nature is that of Muller's ratchet, a seemingly irreversible accumulation of deleterious mutations that all organisms have to deal with or face extinction. The most obvious way to avoid fitness collapse is recombination, though asexual populations usually do not have the luxury of recombining freely. READ MORE

  5. 23. Mechanisms of adaptive mutations in bacteria

    Author : Elisabeth Kugelberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Bacteria have the ability to adapt to various challenging environments. The rate, extent and consequences of bacterial adaptation depend on both microbial and environmental factors. READ MORE

  6. 24. Alzheimer's disease mutations and cellular signalling

    Author : Monika Vestling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease is the most frequent cause of dementia in elderly and is characterised neuropathologically by the extracellular deposition of amyloid plaques (containing the 39-43 amino acid Abeta peptide), as well as intracellular neurofibrillary tangles (NFTs) composed primarily of an abnormally hyperphosphorylated form of the microtubule-associated protein tau. A proportion (10- 15%) of Alzheimer's disease cases is familial, the remainder being sporadic. READ MORE

  7. 25. Understanding Cancer Mutations by Genome Editing

    Author : Muhammad Akhtar Ali; Tobias Associate Professor; Thierry Soussi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genome editing; rAAV; ZBED6; DIP2C; KRAS; BRAF; colorectal cancer; tumor driver genes; cancer pathways;

    Abstract : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. READ MORE