Search for dissertations about: "mycobacterium tuberculosis isoniazid"

Showing result 1 - 5 of 20 swedish dissertations containing the words mycobacterium tuberculosis isoniazid.

  2. 1. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

    Author : Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. READ MORE

  4. 2. Drug resistance in mycobacterium tuberculosis

    Author : Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

    Abstract : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. READ MORE

  5. 3. General awareness of HIV, tuberculosis co-infections and the quality of life among patients with HIV in Xinjiang, in western China

    Author : Rena Maimaiti; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; tuberculosis; quality of life; prevention; pregnancy; isoniazid prophylaxis; treatment outcome;

    Abstract : Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are major public health problems, particularly in low and middle-income countries. China has the second-highest number of TB cases per year in the world. The overall aims of my thesis were to analyze awareness of HIV and identify measures for its prevention. READ MORE

  6. 4. Molecular epidemiology of tuberculosis

    Author : Ramona Groenheit; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy tuberculosis may be a mortal disease. READ MORE

  7. 5. Molecular epidemiology of tuberculosis

    Author : Ramona Petersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tuberculosis (TB) is a global epidemic, with one third of the world's population infected, at least 9 million new active cases per year and about 2 million deaths per year. Without adequate chemotherapy treatment TB may be a mortal disease. READ MORE