Search for dissertations about: "myelin basic protein"
Showing result 11 - 15 of 20 swedish dissertations containing the words myelin basic protein.
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11. Sample preparation and mass spectrometry in proteome studies
Abstract : Proteome studies aim to link gene to function. Instead of screening for function in a specific protein as in classical protein chemistry, proteins are now screened against a specific phenotype, disease or metabolic state. READ MORE
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12. Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation
Abstract : Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile regulators of gene expression, amidst skepticism regarding the biological usefulness of pervasive genomic transcription and its non-coding RNA products prevalent in most eukaryotes. READ MORE
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13. Susceptibility gene mapping in multiple sclerosis
Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease characterized by relapsing or progressive demyelination of the central nervous system (CNS). Increasing evidence supports that genetic factors confer susceptibility to MS resulting in an unknown mode of inheritance as a complex trait. READ MORE
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14. The Role of Matrix Metalloproteinases in Leukocyte Transmigration in Murine Experimental Autoimmune Encephalomyelitis
Abstract : Murine experimental autoimmune encephalomyelitis (EAE) is a commonly used model in the investigation of the human disease multiple sclerosis (MS), a debilitating inflammatory disease of the central nervous system (CNS). MS and EAE involve multiple steps, primarily, auto-antigenic leukocyte (mainly T-cells and macrophages) crossing the blood-brain barrier and later their invasion into the CNS where they degrade myelin basic protein, eventually resulting in axonal degradation and CNS inflammation. READ MORE
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15. Studies of mRNA transport and localization
Abstract : During mRNA biogenesis, a subset of newly exported mRNA is assembled into larger RNA granules which are transported to subcellular compartments for localized translation. These mechanisms are critical for asymmetric mRNA and protein distribution and have profound impact on cellular physiology. READ MORE