Search for dissertations about: "myelin"

Showing result 11 - 15 of 127 swedish dissertations containing the word myelin.

  2. 11. Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia : New role of heat shock protein, nitric oxide and carbon monoxide : an experimental study in rat using light and electron microscopy

    Author : Hari Shanker Sharma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; blood-brain barrier; heat stress; hyperthermia; brain edema; serotonin; nitric oxide; carbon monoxide; heat shock protein; glial fibrillary acidic protein; myelin basic protein; opioids; histamine; catecholamines; naloxone; indomethacin; p-CPA; electron microscopy; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

    Abstract : This thesis deals with the molecular mechanisms of hyperthermia induced brain damage in rats. The results clearly establish that hyperthermia caused by 4 h heat stress at 38° C is associated with a breakdown of the blood-brain barrier (BBB) permeability which seems to be instrumental in causing brain edema and cell injury. READ MORE

  4. 12. Strategies to explore the membrane proteome of a cell

    Author : Gianluca Maddalo; Leopold L. Ilag; Peter James; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Membrane proteins; Proteomics; Escherichia coli; Enterococcus faecalis; Synechocystis; Mass Spectrometry; BN SDS-PAGE; FT-ICR-MS; Myelin P2 protein; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : The cell envelope plays key roles in numerous processes such as maintaining cellular integrity, communication with other cells, signal transduction, maintenance of cellular homeostasis, and regulation of the traffic of molecules between the cell and the extracellular milieu. Essential membrane components in many of these processes are proteins. READ MORE

  5. 13. Multiple Sclerosis: Studies of the Interferon system and search for infectious agents

    Author : My Bergkvist; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; Axon and myelin damage; IgG; Virus; Interferon; Multiple Sclerosis; Genetic linkage;

    Abstract : Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. READ MORE

  6. 14. Immunogenetics and treatment of experimental autoimmune encephalomyelitis

    Author : Robert Weissert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; experimental autoimmune encephalomyelitis; major histocompatibility complex; myelin; myelin oligodendrocyte glycoprotein; T cell receptor;

    Abstract : Experimental autoimmune encephalomyelities (EAE) is a model of multiple sclerosis (MS). This experimental central nervous system (CNS) disease can be induced in rats by immunization with components of the CNS myelin sheath. READ MORE

  7. 15. Suppressive DNA vaccination in experimental autoimmune encephalomyelitis

    Author : Anna Lobell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccination; autoimmunity; experimental autoimmune encephalomyelitis; multiple sclerosis; T cell receptor; CpG motif; myelin basic protein; myelin oligodendrocyte glycoprotein;

    Abstract : This thesis describes the development of a novel method to suppress an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), by vaccination with DNA encoding autoantigenic peptides. DNA vaccination can produce long-term immunity and generate antigen-specific CD8+ and CD4+ T cells. READ MORE