Search for dissertations about: "myelodysplastic syndromes"

Showing result 1 - 5 of 28 swedish dissertations containing the words myelodysplastic syndromes.

2. 1. Population-based studies in Myelodysplastic syndromes : Prognostic scores, socioeconomic status, and therapy-related disease

   Author : Daniel Moreno Berggren; Elisabeth Ejerblad; Sören Lehmann; Martin Jädersten; David Bowen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myelodysplastic syndromes; Chronic myelomonocytic leukaemia; Prognostication; Comorbidity; Therapy-related disease; Real-world data; Population-based studies; Medicinsk vetenskap; Medical Science;

   Abstract : The aim of this thesis was to expand the epidemiological knowledge of the haematological malignancy MDS and the related condition chronic myelomonocytic leukaemia (CMML). Using nationwide registers, the papers in this thesis address aspects of prognostication, comorbidity, socioeconomic status, and therapy-related disease, using a population-based approach. READ MORE

4. 2. Studies of anemia in the myelodysplastic syndromes

   Author : Martin Jädersten; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Myelodysplasia; growth factors; Cox regression; delayed entry; left truncation; mortality; international prognostic scoring system; IPSS; who-classification based prognostic scoring system; WPSS; thalidomide analogue; IMiD; hematopoietic stem cell; adhesion; stroma; matrix; osteonectin; matricellular protein; NPM1; immunohistochemistry.;

   Abstract : Background: The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders, characterized by chronic anemia and increased risk of transformation to acute myeloid leukemia (AML). The first line therapy of anemia in MDS is erythropoietin (EPO) with or without granulocyte colony-stimulating factor (G-CSF). READ MORE

5. 3. Improving prognostication for patients with myelodysplastic syndromes

   Author : Maria Creignou; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background and aims: MDS constitute a heterogenous group of myeloid malignancies mainly characterized by dysfunctional hematopoiesis. Although cytopenia, dysplastic features and evidence of clonality are essential criteria for the diagnosis of all MDS, the several subtypes of the disease have a highly variable prognosis. READ MORE

6. 4. TP53 mutations in myelodysplastic syndromes with deletion of 5q

   Author : Leonie Saft; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia(s) and increased risk of progression to acute myeloid leukemia (AML). International Prognostic Scoring system (IPSS) Low- or Intermediate (INT)-1 risk MDS with a deletion of 5q (del5q) were considered to have an indolent course and a low risk for progression to AML as compared to other MDS subtypes. READ MORE

7. 5. Modelling ineffective erythropoiesis in myelodysplastic syndromes with ring sideroblasts

   Author : Edda María Elvarsdóttir; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Myelodysplastic syndromes with ring sideroblast (MDS-RS) is a clonal hematological malignancy characterized by accumulation of iron filled erythroblasts called ring sideroblasts in the bone marrow, and recurrent somatic mutations in the splicing factor gene SF3B1. The disease mainly affects elderly individuals, causing severe anemia in patients for which no curative treatment exists. READ MORE