Search for dissertations about: "myelodysplastic syndromes"
Showing result 16 - 20 of 28 swedish dissertations containing the words myelodysplastic syndromes.
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16. Chronic bone marrow failure and transfusion patterns : epidemiological studies of blood transfusions and outcomes in patients with myelodysplastic syndromes
Abstract : Myelodysplastic syndromes (MDS) encompass a diverse group of clonal hematological malignancies characterized by dysplasia and ineffective hematopoiesis with an increased risk of leukemic evolution. It is a disease of the elderly with a median age of nearly 75 years. READ MORE
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17. Clinical - cytogenetic correlations in malignant hematologic disorders
Abstract : In the present thesis, clinicogenetic correlations are investigated in a large population-based series of acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), acute lymphoblastic leukemia, and chronic myeloid leukemia, for which the karyotypes were analyzed at the same center. The karyotypic pattern, i.e. READ MORE
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18. Exploring the role of epigenetic alterations in myeloid malignancies with focus on drug response
Abstract : The production of blood cells (hematopoiesis), where the hematopoietic stem cell (HSC) is the cell of origin of all blood cells, is regulated by a complex network of intrinsic and extrinsic signals. Dysregulation of hematopoiesis, including somatic heterozygous mutations, cytogenetic aberrations, or epigenetic aberrations, are found in hematological malignancies. READ MORE
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19. Trisomies in Hematologic Malignancies
Abstract : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. READ MORE
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20. Mechanisms influencing natural killer cell recognition of tumour cells
Abstract : Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK cells with increased functionality. The process leading to gain of function through inhibition is known as NK cell education. READ MORE