Search for dissertations about: "myelodysplastic syndromes"

Showing result 21 - 25 of 28 swedish dissertations containing the words myelodysplastic syndromes.

  2. 21. Genetic analyses of multiple myeloma and related plasma cell dyscrasias

    Author : Therese Nilsson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetik; cytogenetik; cytogenetics; Genetics; FISH; cytogenetic; multiple myeloma; MGUS;

    Abstract : Acquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias. READ MORE

  4. 22. Sequencing cancer

    Author : Una Kjällquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer forms highly heterogeneous tissues at several molecular levels, genomic, proteomic, transcriptomic and other epigenetic traits. The level of complexity is further augmented by the dynamic nature of tumor progression with cancer cell populations evolving in a clonal manner. READ MORE

  5. 23. DNA methylation in T cell leukaemia

    Author : Maike Bensberg; Colm Nestor; Maria Jenmalm; Sofie Degerman; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. READ MORE

  6. 24. Molecular specificities of NK cell-mediated recognition of human tumor cells

    Author : Mattias Carlsten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addressed the molecular specificity of NK cell-mediated recognition of freshly isolated human tumor cells. READ MORE

  7. 25. Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients

    Author : Eva Ösby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aggressive; non-Hodgkin s lymphoma; elderly; CHOP; mitoxantrone; etoposide; G-CSF; response evaluation; longevity;

    Abstract : The age-adjusted incidence rate of non-Hodgkin´s lymphoma (NHL), in particular diffuse large B cell lymphoma, has increased continuously during several decades. Patients with aggressive NHL are potentially curable but the 5-year overall survival (OS) is still less than 50% in the whole group. READ MORE