Search for dissertations about: "myelodysplastic syndromes"

Showing result 6 - 10 of 28 swedish dissertations containing the words myelodysplastic syndromes.

2. 6. Apoptosis in myelodysplastic syndromes : effects of hemopoietic growth factors

   Author : Ramin Tehranchi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Increased apoptosis of hernatopoietic progenitors is a hallmark of myelodysplastic syndromes (MDS) and results in ineffective hematopoiesis. Erythroid apoptosis is thought to be the main mechanism underlying the severe anemia observed in the low-risk subgroups, refractory anemia (RA) arid RA with ringed sideroblasts (RARS). READ MORE

4. 7. Identification and Characterization of Stem Cells in Preleukemia and Leukemia

   Author : Lars Nilsson; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; extracellulära vätskor; Hematologi; Philadelphia chromosome; acute lymphoblastic leukemia; polycytemia vera; 5q- syndrome; myelodysplastic syndromes; self-renewal; preleukemia; Hematopoietic stem cells; leukemic stem cells; extracellular fluids;

   Abstract : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. READ MORE

5. 8. Clinical and molecular effects of azacitidine in the myelodysplastic syndromes

   Author : Magnus Tobiasson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders characterized by peripheral cytopenia and increased risk of leukemic progression. In higher-risk MDS, Azacitidine has been shown to prolong survival and modulate the epigenome, although the precise mechanisms by which the drug exerts its effect are unknown. READ MORE

6. 9. Apoptosis in the myelodysplastic syndromes : protective effect of G-CSF

   Author : Jan Schmidt-Mende; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Increased apoptosis of hematopoietic progenitor cells is a hallmark for the myelodysplastic syndromes (MDS), and one of the main reasons for the ineffective hematopoiesis and subsequent cytopenia characteristic for the disease. In particular in low risk MDS, such as refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS), severe transfusion-dependent anemia leading to constant fatigue and weakness and therefore reduced quality of life often constitutes the main clinical problem. READ MORE

7. 10. Interphase cytogenetics and cytokine therapy in myelodysplastic syndromes and acute myeloid leukemia

   Author : Per Bernell; Karolinska Institutet; Karolinska Institutet; []
   Keywords : myelodysplastic syndromes; acute myeloid leukemia; FISH; clonality; lineageinvolvement; minimal residual disease; EIPO; GM-CSF.;

   Abstract : Myelodysplastic syndromes (MDS) comprise a group of clonal hematopoietic bone marrow cell disorders, characterized by a variable degree of anemia, granulocytopenia and/or thrombocytopenia and with a substantial risk of transformation to acute myeloid leukemia (MDS-AML). In the present thesis a method based on fluorescence in situ hybridization (FISH) was developed which allows cytogenetic studies on morphological identified peripheral blood and bone marrow cells (MGG/FISH). READ MORE