Search for dissertations about: "myeloid leukemia"
Showing result 16 - 20 of 194 swedish dissertations containing the words myeloid leukemia.
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16. Prognostic markers in acute myeloid leukemia : A candidate gene approach
Abstract : The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. READ MORE
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17. Receptors and Regulators of Myeloid Leukemia
Abstract : .... READ MORE
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18. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia
Abstract : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. READ MORE
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19. Redox reactions in cancer: impact and regulation
Abstract : The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of myeloid cells, NOX2, is a major source of oxidants in the form of reactive oxygen species (ROS), which are short-lived oxygen derivatives. READ MORE
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20. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia
Abstract : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. READ MORE