Search for dissertations about: "myocardial infarction, genetic markers"

Showing result 1 - 5 of 11 swedish dissertations containing the words myocardial infarction, genetic markers.

2. 1. Innate immunity in human atherosclerosis and myocardial infarction : Role of CARD8 and NLRP3

   Author : Geena Paramel Varghese; Karin Fransén; Allan Sirsjö; Liza Ljungberg; Johan Frostegård; Örebro universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Inflammasome; NLRP3; CARD8; Myocardial infarction; Endothelial cells; Polymorphism; IL-1β; Cytokines; Innate immunity; Biomedicin; Biomedicine;

   Abstract : Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). READ MORE

4. 2. Tissue Factor and CD40 Ligand : Markers for the Interplay of Coagulation and Inflammation in the Acute Coronary Syndrome

   Author : Anders Mälarstig; Agneta Siegbahn; Lars Wallentin; Taavo Tenno; Fiona Green; Uppsala universitet; []
   Keywords : Molecular medicine; tissue factor; CD40 ligand; gene expression; single nucleotide polymorphism; acute coronary syndrome; myocardial infarction; coagulation; inflammation; Molekylärmedicin;

   Abstract : BACKGROUND: Tissue factor (TF) is a 47 kDa transmembrane glycoprotein known as the main initiator of blood coagulation. CD40 ligand is another membrane molecule, which ligates to cell types associated with atherosclerotic plaques thereby mediating intraplaque inflammation and weakening of the fibrous cap. READ MORE

5. 3. Insulin resistance, genetic variation and cytokines : associations to myocardial infarction risk

   Author : Anna Bennet; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Insulin resistance, inflammation and associated genes are considered as factors of potential importance for the pathogenesis of cardiovascular diseases, but their relationship to myocardial infarction (MI) and associated risk factors remains unclear. In the present thesis, insulin resistance and serum levels as well as genetic variants of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha), were investigated in the population-based study "the Stockholm heart epidemiological program" (SHEEP) (n=5452). READ MORE

6. 4. Biomarkers of Renal Function in Acute Coronary Syndromes

   Author : Axel Åkerblom; Stefan James; Lars Wallentin; Torbjörn Omland; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystatin C; glomerular filtration rate; GFR; creatinine; acute coronary syndrome; ACS; kidney; renal; mortality; death; myocardial infarction; Cardiology; Kardiologi; Medicin; Medicine; Internal Medicine; Internmedicin;

   Abstract : The thesis aimed to investigate cystatin C and creatinine-based estimates of glomerular filtration rate (eGFR), both at admission and during follow-up, on the combined endpoint of cardiovascular death and myocardial infarction in patients with acute coronary syndrome (ACS). We also evaluated two cystatin C assays and assessed genetic determinants of cystatin C concentrations. READ MORE

7. 5. Genetic studies in rheumatoid arthritis : familial studies and analysis of relationships to atherothrombotic comorbidity

   Author : Lisbeth Ärlestig; Solbritt Rantapää Dahlqvist; Dan Holmberg; Åsa Torinsson Naluai; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; genetics; familial studies; ACPA and cardiovascular co-morbidity; reumatologi; rheumatology; genetik; Genetics; cardiovascular disease; hjärt- och kärlforskning;

   Abstract : Background. Rheumatoid arthritis (RA) is an autoimmune disease mainly affecting the joints but has also extra articular manifestations and an increased cardiovascular (CV) co-morbidity. Rheumatoid factor (RF) and antibodies against citrullinated proteins/peptides (ACPA) are diagnostically important and are related to a more severe disease. READ MORE