Search for dissertations about: "myocardial infarction rat"

Showing result 1 - 5 of 29 swedish dissertations containing the words myocardial infarction rat.

  2. 1. Myocardial creatine metabolism in experimental infarction and heart failure

    Author : Malin Lindbom; Göteborgs universitet; []
    Keywords : Energy metabolism; Creatine; Congestive heart failure; Myocardial infarction; Ventricular arrhythmias; Cardiac remodeling; apolipoprotein B; Lipid metabolism;

    Abstract : The failing heart is characterized by changes in structure, function and metabolism. All these changes are usually defined as pathologic remodelling. An important part of this negative remodelling process is disturbances in the myocardial energy metabolism. READ MORE

  4. 2. Structural, functional and metabolic effects of growth hormone on nomal and failing heart

    Author : Entela Bollano; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; myocardial infarction; echocardiography; magnetic resonance spectroscopy; left ventricular remodelling;

    Abstract : The growth hormone/insulin-like growth factor I (GH/IGF-I) system plays an important role for cardiac development, structure and function. Recently, data from experimental and clinical studies have suggested the use of GH as treatment after myocardial infarction (MI) affecting cardiac remodeling and development of heart failureThe aim of this thesis was to study the effects of GH on cardiac structure, function and energy metabolism in normal and failing heart. READ MORE

  5. 3. Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods

    Author : Xiaojin Hao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; arteriogenesis; apoptosis; myocardial infarction; VEGF-A165; bFGF; PDGF-BB; adenovirus; plasmid; alginate;

    Abstract : Angiogenesis, the stimulation of vessel growth, is a promising therapy in ischemic heart disease. A wealth of evidence has shown that several growth factors can induce neovascularization in ischemic models. However, the optimal application of growth factors and delivery method requires further exploration. READ MORE

  6. 4. Myocardial angiogenesis : aspects on endogenous determinants and effects of stimulation

    Author : Agneta Månsson Broberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myocardial infarction; ischemia; angiogenesis; VEGF- A165; gene therapy; adenovirus; plasmid; ephrinB2; darbepoietin-alpha; apoptosis; estrogen receptors;

    Abstract : Background: Therapeutic angiogenesis using i.e. VEGF and FGF have shown beneficial effects, however, delivery routes and other modulating agents have not been thoroughly investigated. In this study the efficacy of adenovirus gene transfer was compared to plasmid gene transfer. READ MORE

  7. 5. Endothelin and nitric oxide in coronary vascular regulation with special reference to myocardial ischemia/reperfusion injury

    Author : Qing-Dong Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : endothelium; endothelin; myocardial ischemia; myocardial infarction; reperfusion; L-arginine; nitric oxide.;

    Abstract : The vascular endothelium plays an important role in the regulation of cardiovascular function by producing bioactive substances such as nitric oxide (NO) and endothelin-I (ET- 1). Recent evidence has revealed that endothelial dysfunction is closely related to myocardial ischemia/reperfusion injury. READ MORE