Search for dissertations about: "myopathies"

Showing result 1 - 5 of 46 swedish dissertations containing the word myopathies.

2. 1. Immunopathogenic mechanisms in inflammatory myopathies

   Author : Pernilla Englund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Myositis; capillaries; muscle fibers; IL-1 alpha; MHC; adhesion molecules;

   Abstract : The idiopathic inflammatory myopathies (IIMs) are characterized by symmetrical, proximal muscle weakness and by inflammatory infiltrates in muscle tissue. Based on different clinical as well as histopathological features the IlMs can be separated into polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). READ MORE

4. 2. The muscle cytoskeleton of mice and men : Structural remodelling in desmin myopathies

   Author : Lena Carlsson; Lars-Eric Thornell; Anders Arnér; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desmin; nestin; synemin; paranemin; plectin; αB-crystallin; skeletal muscle; heart muscle; myotendinous junction; motor endplate; costamere; anatomi; Human Anatomy;

   Abstract : The muscle fibre cytoskeleton of skeletal and heart muscle cells is composed mainly of intermediate filaments (IFs), that surround the myofibrils and connect the peripheral myofibrils with the sarcolemma and the nuclear membrane. Desmin is the first muscle specific IF protein to be produced in developing muscles and is the main IF protein in mature muscles. READ MORE

5. 3. Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics

   Author : Joachim Piguet; Horst Vogel; Ruud Hovius; Jerker Widengren; Antoine Triller; Switzerland Ecole Polytechnique Fédérale de Lausanne (EPFL); []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fluorescence; microscopy; plasma membrane; membrane proteins; membrane proteins diffusion; single-molecule imaging; single-molecule tracking; pentameric ligand-gated ion channels; nicotinic acetylcholine receptor; serotonin receptor; synapse; neuromuscular junction; post-synaptic scaffold; rapsyn; myopathies; fluorescent proteins; Förster resonance energy transfer; FRET imaging; protein-protein interactions; protein trafficking; photo-activatable proteins; Biological Physics; Biologisk fysik;

   Abstract : Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotinic acetylcholine is densely packed under the motor nerve termini. READ MORE

6. 4. Multifaceted roles of the transmembrane nuclear envelope protein, Samp1

   Author : Mohammed Hakim Jaffer Ali; Einar Hallberg; Giovanna Lattanzi; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope; transmembrane protein interaction studies; cell differentiation; stem cells; myopathies; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. READ MORE

7. 5. Pathogenic mechanisms in idiopathic inflammatory myopathies

   Author : Cecilia Grundtman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Idiopathic inflammatory myopathies (IIMs) are chronic inflammatory disorders characterized by muscle weakness, by low muscle endurance, and by inflammation in skeletal muscle tissue. The pathogenesis and etiology of these conditions are yet not fully understood and several different mechanisms are likely to be involved. READ MORE