Search for dissertations about: "nachrs"

Showing result 1 - 5 of 28 swedish dissertations containing the word nachrs.

2. 1. Maf transcription factors in beta cell function

   Author : Elvira Ganic; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

   Abstract : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. READ MORE

4. 2. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

   Author : Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

   Abstract : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. READ MORE

5. 3. Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease

   Author : Jin Xiu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Nicotinic acetylcholine receptor; Alzheimer s disease; glia cells; Abeta; cholesterol; cholesterollowering drugs;

   Abstract : Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of many processes including synapses regeneration, neurotransmission and neuroprotection in the central nervous system (CNS). There is increasing evidence for the disturbances in nAChRs in Alzheimer's disease (AD). READ MORE

6. 4. Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice

   Author : Amelia Marutle; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Ageing; Alzheimer s disease; P-amyloid; Nicotinic acetylcholine receptor subtypes; Postmortem human brain; Schizophrenia; Transgenic mice;

   Abstract : Neuronal nicotinic acetylcholine receptors (nAChRs) are transmitter-gated ion channel receptors which are widely distributed in the brain. They mediate the effects of several neurotransmitters including ACh, DA, 5-HT and NA and are important for many normal physiological functions in the brain and are also implicated in a number of CNS disorders, such as AD, PD, schizophrenia, Tourette's syndrome and familial epilepsy. READ MORE

7. 5. Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease

   Author : Christina Unger; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Abeta; Alzheimer s disease; APP; nAChR; NMDA receptors; synaptophysin; transgenic mice; treatment;

   Abstract : The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial questions are if Abeta has a neuronal function in the brain and how it interacts with the neurotransmitter system in AD. READ MORE