Search for dissertations about: "nanoparticles gene delivery"

Showing result 1 - 5 of 12 swedish dissertations containing the words nanoparticles gene delivery.

2. 1. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis

   Author : Moataz Dowaidar; Ülo Langel; Sandrine Sagan; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; magnetic nanoparticles; graphene oxide; autophagy; siRNA; SCO; QSAR; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. READ MORE

4. 2. Linear and Branched Chitosan Oligomers as Delivery Systems for pDNA and siRNA In Vitro and In Vivo

   Author : Mohamed Mahmoud Issa; Per Artursson; Arto Urtti; Uppsala universitet; []
   Keywords : Medical sciences; Chitosan oligomers; gene delivery; gene expression; pDNA; siRNA; MEDICIN OCH VÅRD;

   Abstract : In this thesis, chitosan, a biocompatible polysaccharide that has been approved as a food additive was selected as a platform for the development of safe, efficient non-viral gene delivery systems to mammalian cells. Previously, chitosan-based gene formulations had been generally associated with high molecular weight chitosans, which were poorly characterised in terms of molecular weight distribution and degree of acetylation. READ MORE

5. 3. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations

   Author : Tõnis Lehto; Ülo Langel; Patrick Midoux; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transfection; gene delivery; oligonucleotide; complexes; non-viral; in vivo; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. READ MORE

6. 4. Biocompatibility of synthetic nanomaterials and their applications in gene delivery

   Author : Jingwen Shi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Nanomedicine is the use of nanoscale or nanostructured materials in medicine that due to their structure have unique medical effects. Prominent applications of nanomedicine are the use of nanomaterials for the delivery of drugs and nucleic acids (to correct gene defects). READ MORE

7. 5. Acylated cell-penetrating peptides for nucleic acid delivery

   Author : Tönis Lehto; Ülo Langel; Eric Johnston; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; nucleic acid delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : In recent decades many new methods have been developed to cure or treat genetical disorders such as cancer, viral infections or inheritable diseases. The problem is that the nucleic acids and their synthetic analogs, oligonucleotides, are not able to cross the cell membrane due to their physicochemical properties like high negative charge and size. READ MORE