Search for dissertations about: "nasal route thesis"

Showing result 1 - 5 of 14 swedish dissertations containing the words nasal route thesis.

2. 1. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption

   Author : Cecilia Wadell; Frans Merkus; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

   Abstract : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. READ MORE

4. 2. Olfactory Transfer of Analgesic Drugs After Nasal Administration

   Author : Ulrika Espefält Westin; Erik Björk; Eva Brittebo; Margareta Hammarlund-Udenaes; Paolo Colombo; Uppsala universitet; []
   Keywords : Pharmaceutics; Nasal administration; Olfactory transfer; Olfactory pathways; Central nervous system; Blood-brain barrier; Nasal respiratory mucosa; Olfactory mucosa; Olfactory bulb; Horizontal Ussing chamber; Morphine; Dihydroergotamine; Rat; Mouse; Swine; Autoradiography; Viability; Powder formulations; Galenisk farmaci;

   Abstract : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. READ MORE

5. 3. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

   Author : Björn Jansson; Erik Björk; Sveinbjörn Gizurarson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Administration; intranasal; Nasal mucosa; Central nervous system; Olfactory bulb; Rat; Mouse; Swine; Cattle; Diffusion chambers; culture; In vitro; Biological models; Biological transport; Dextrans; Dopamine; Gels; Polysaccharides; Autoradiography; Fluorescence microscopy; Biofarmaci; Biopharmacy; Biofarmaci;

   Abstract : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. READ MORE

6. 4. The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery : Method Development and Applications Using Different Formulations

   Author : Karin Östh; Anna-Lena Ungell; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

   Abstract : The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. READ MORE

7. 5. Modulation of experimental T cell autoimmunity in the nervous system with emphasis on nasal tolerance

   Author : Xue-Feng Bai; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Experimental autoimmune neuritis (EAN) and encephalomyelitis (EAE) are animal models of Guillian-Barre syndrome (GBS) and multiple sclerosis (MS), representing human demyelinating diseases of the peripheral nervous system (PNS) and central nervous system (CNS), respectively. CD4+ T cells recognizing myelin antigens and producing cytokines play central roles in the pathogenesis of both EAN and EAE and perhaps of GBS and MS. READ MORE