Search for dissertations about: "nasopharyngeal carcinoma"

Showing result 26 - 30 of 32 swedish dissertations containing the words nasopharyngeal carcinoma.

  2. 26. The interactome of the Epstein-Barr virus nuclear antigen 5 suggests novel roles in RNA and protein metabolism

    Author : Josefine Ekholm; Göteborgs universitet; []
    Keywords : Epstein-Barr virus; EBNA5; chaperone; proteasome; nucleolus;

    Abstract : Epstein-Barr virus (EBV) is a human herpes virus that infects B and epithelial cells of the oropharynx. EBV is transmitted by saliva and establishes a lifelong latency in over 90% of the world's population. During latency, the virus exists predominantly as multicopy episomes in the nuclei of memory B cells. READ MORE

  4. 27. The Epstein-Barr nuclear antigens 1 & 5; Study of virus-host cellular protein interactions

    Author : Alma Forsman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; EBNA1; EBNA5; EBNA-LP; cellular network; virus-host protein interactions;

    Abstract : The Epstein-Barr virus (EBV) is the causative agent or cofactor in the aetiology of several human malignancies such as Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma (NPC) and lymphoproliferative disorder in immunocompromised patients. EBV is a lymphotropic γ-herpes virus infecting more than 90 percent of the population worldwide. READ MORE

  5. 28. Immunoregulatory properties of CD137-CD137 ligand axis in tumours and chronic inflammatory conditions

    Author : Luu Nguyen Khang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : CD137 (4-1BB/TNFRSF9) is a member of the TNF receptor superfamily. CD137 expression is activation-dependent, and usually reported on T cells and NK cells. Its natural ligand is CD137 ligand (CD137L), mainly found on antigen-presenting cells (APC) such as monocytes, or dendritic cells. READ MORE

  6. 29. The role of the microenvironment on the regulation of Epstein-Barr virus latent gene expression

    Author : Loránd Levente Kis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epstein-Barr virus (EBV) is a human-specific gamma-herpes virus of the Lymphocryptovirus genus that has succeeded to colonize more than 90% of the adult population. EBV s coevolution with humans has established a largely harmless co-existence that depends on the variability of viral gene expression and on the immunological host response. READ MORE

  7. 30. Transcriptional regulation of the latent membrane protein 1 gene by Epstein-Barr virus nuclear antigen 2

    Author : Lars Palmqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; EBNA2; transcription; phosphorylation; histone acetylation;

    Abstract : The Epstein-Barr virus (EBV) is a ubiquitous human herpes virus, which infects B-cells. This leads to a life-long latent infection, which in most cases is non-pathogenic. However, EBV is etiologically associated with several human malignancies, including endemic Burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoma. READ MORE