Search for dissertations about: "natural killer cells"

Showing result 21 - 25 of 198 swedish dissertations containing the words natural killer cells.

  2. 21. Studies of the recognition and activation of natural killer cells

    Author : Clas Une; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; activation; cytotoxicity; IFN-[gamma] IFN-[alpha] [beta]; IL-12; G-PI; MHC class I;

    Abstract : Natural killer (NK) cells mediate part of the innate immune response that impedes the spread of invading microorganisms and shapes the downstream adaptive immune response. NK cells spontaneously kill tumor cells and other cells upon contact. Killing requires engagement of germline encoded receptors that mediate positive and negative signals. READ MORE

  4. 22. Genetic modification of human natural killer cells and possible applications thereof

    Author : Kyriakos Konstantinidis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Natural killer cells; retroviral transduction; interleukin-2; endoplasmic reticulum targeting; green fluorescent protein; multiple myeloma;

    Abstract : Natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2) for their survival and for their cytotoxicity against tumor cells. Currently, for in vitro expansion of NK cells from peripheral blood mononuclear cells (PBMCs), IL-2 is of great importance. READ MORE

  5. 23. Diabetes pathogenesis : role of natural killer cells, T cells and a novel neuropeptide

    Author : Hanna Brauner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes is a major health problem affecting nearly 5% of the population world wide. It is a heterogeneous group of diseases with the autoimmune type 1 diabetes (T1D) and the metabolic type 2 diabetes (T2D) being the major types. READ MORE

  6. 24. Natural killer T cell subsets and regulation of autoimmune diabetes

    Author : Martin Stenström; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; transplantation; CD1d; NKT cells; Immunology; autoimmune diabetes; serologi; Immunologi;

    Abstract : This thesis is focused on natural killer (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. READ MORE

  7. 25. Natural killer cells in cancer : studies on migration and cytotoxicity

    Author : Erik Wennerberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. Despite these recent advances the clinical success has to date been modest in treatment of solid tumors, owing both to suboptimal directed migration of NK cells and the tumor cell’s resistance to NK cell-mediated lysis. READ MORE