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Showing result 1 - 5 of 444 swedish dissertations matching the above criteria.

2. 1. Experimental Evolution : and Fitness Effects of Mutations

   Author : Anna Knöppel; Dan I Andersson; Stanley Maloy; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Fitness effects; mutations; S20; fis; ribosome; horizontal gene transfer; adaptation; synonymous mutations; Mikrobiologi; Microbiology;

   Abstract : Bacteria have small, streamlined genomes and evolve rapidly. Their large population sizes allow selection to be the main driver of evolution. With advances in sequencing technologies and precise methods for genetic engineering, many bacteria are excellent models for studying elementary questions in evolutionary biology. READ MORE

4. 2. Vitreoscilla Haemoglobin - Peroxidase Activity and Metabolic Aspects

   Author : Malin Kvist; Tillämpad biokemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; metabolism; Biokemi; Metabolism; Biochemistry; Naturvetenskap; Natural science; lipid peroxidation; hypoxia; salt stress; Escherichia coli; Lactococcus lactis; hydrogen-bonding network; proximal site; mutations; Vitreoscilla haemoglobin; peroxidase activity; Proteins; enzymology; Proteiner; enzymologi;

   Abstract : The function of non-vertebrate haemoglobins (Hbs) appears more diverse than that of vertebrate Hbs, possibly reflecting the various demands to be met among their hosts. Sharing structural features with other haem proteins/enzymes, Hbs display a qualitative overlap in activities with functions extending beyond oxygen transport/storage. READ MORE

5. 3. The effects of deleterious mutations on ageing

   Author : Martin Iinatti Brengdahl; Urban Friberg; Dominic Wright; Thomas Flatt; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ageing; Age-specific effects; Deleterious mutations; Drosophila melanogaster; Lifespan; Sex differences;

   Abstract : Ageing is defined as the deterioration of an individual's physiological performance with advancing age, which leads to a decrease in reproduction and/or survival. The question why most organisms age has preoccupied humans for millennia and, over the last decades, resulted in an ever-increasing research effort to understand this phenomenon. READ MORE

6. 4. Neurospora tetrasperma from Natural Populations : Toward the Population Genomics of a Model Fungus

   Author : Pádraic Corcoran; Hanna Johannesson; Sylvain Glemin; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurospora; poulation genetics; genomes; introgression; Evolutionary Genetics; Evolutionär genetik;

   Abstract : The study of DNA sequence variation is a powerful approach to study genome evolution, and to reconstruct evolutionary histories of species. In this thesis, I have studied genetic variation in the fungus Neurospora tetrasperma and other closely related Neurospora species. I have focused on N. READ MORE

7. 5. Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds

   Author : Jenny Aasa; Margareta Törnqvist; Elaine M. Faustman; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; glycidol; 3-monochloropropane-1; 2-diol 3-MCPD ; genotoxicity; mutations; micronuclei; hemoglobin adducts; in vivo dose; multiplicative risk model; cancer risk assessment; human cancer risk; miljökemi; Environmental Chemistry;

   Abstract : Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glycidol, which is genotoxic and an animal carcinogen. It is the model compound of this work, partly due to its presence in food. READ MORE