Search for dissertations about: "necrotic"

Showing result 16 - 20 of 97 swedish dissertations containing the word necrotic.

  2. 16. Novel endogenous mechanisms of complement regulation - A delicate balance

    Author : Andreas Holmér; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Abstract : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. READ MORE

  4. 17. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

    Author : Alexander Pietras; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

    Abstract : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. READ MORE

  5. 18. Neuronal apoptosis in excitotoxicity : involvement of nitric oxide and cytoskeletal damage

    Author : Emanuela Bonfoco; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the nervous system apoptosis may play an important role in the development of several neurodegenerative diseases. The overall objective of the present work is to investigate at the cellular and molecular levels, the mechanisms by which neurons are signaled to undergo apoptotic cell death after exposure to various effectors, such as nitric oxide (NO) and its byproducts, glutamate, and colchicine. READ MORE

  6. 19. Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia

    Author : Michel Ferrand-Drake; Lund Wallenberg Neurocentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; neuronal death; calpain; caspase; mitochondrial permeability transition; necrosis; apoptosis; cerebral ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia Following prolonged disruption of blood flow to the central nervous system (CNS), or energy deprivation by other means, such as hypoglycemia, some cells will inevitably degenerate. It has been, and still is, the subject of considerable debate and intense research on brain ischemia, as to the mode of cell death, i. READ MORE

  7. 20. Improving stroke risk prediction and individualised treatment in carotid atherosclerosis

    Author : Eva Karlöf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. Currently, this risk estimation is based on measurements of stenosis and neurological symptoms, which determines the therapy of either medical treatment with or without carotid endarterectomy. READ MORE