Search for dissertations about: "neointimal hyperplasia"

Showing result 1 - 5 of 9 swedish dissertations containing the words neointimal hyperplasia.

  2. 1. Cardiovascular role of PDGF-B in development and disease. Studies in genetically engineered mice

    Author : Henrik Nyström; Göteborgs universitet; []
    Keywords : atherosclerosis; cardiovascular disease; cell retention; in vivo physiology; neointimal hyperplasia; PDGF; transgenic mice; vascular function; vascular smooth muscle cell;

    Abstract : Platelet-derived growth factor B (PDGF-B) is vital for microvascular development, and retention of PDGF-B to extracellular matrix (ECM) is important in this process. However, the role and source of PDGF-B in development of macrovascular function is disputed. READ MORE

  4. 2. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease

    Author : Lena Brånén; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; cell replication; Cardiovascular system; Kardiovaskulära systemet; spindle-shaped; epithelioid; smooth muscle cells; periadventitial cuff injury; sTNF-R1; bone marrow transplantation; chimeric fusion protein; atherogenic diet; ApoE; TNF-a; genetically altered mice; en face preparation; atherosclerosis; neointimal hyperplasia;

    Abstract : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). READ MORE

  5. 3. Developmental origin and molecular regulation of vascular smooth muscle cells

    Author : Per Wasteson; Göteborgs universitet; []
    Keywords : smooth muscle cell; aorta; cell origin; lateral plate mesoderm; paraxial mesoderm; lipoma preferred partner; serum response factor; neointimal hyperplasia; angiotensin II; platelet-derived growth factor-B;

    Abstract : Several pathologies of the vascular system have been suggested to be dependent on the smooth muscle cells (SMCs) that build up the vessel wall. Aortic SMCs have been proposed to derive from lateral plate mesoderm. READ MORE

  6. 4. The role of the adventitia and perivascular tissue for the formation of intimal hyperplasia

    Author : Per Fogelstrand; Göteborgs universitet; []
    Keywords : Intimal hyperplasia; adventitia; perivascular tissue; smooth muscle cells; fibroblasts; balloon injury; vein graft; artificial graft;

    Abstract : Symptomatic atherosclerosis is commonly treated with balloon angioplasty or bypass surgery. About 30% of the interventions will re-narrow within a year due to restenosis and graft-stenosis. Thickening of the luminal layer, the intima, is an important component in these side-effects. READ MORE

  7. 5. Mechanisms of thrombosis and restenosis after vascular injury

    Author : Carl Magnus Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Restenosis; neointimal hyperplasia; thrombin inhibition; angioplasty; PTA; outcome analysis; coagulation; inflammation; CRP; thioredoxin; oxidative stres;

    Abstract : Atherosclerosis is the underlying cause of about 50% of all deaths in the western world. Peripheral vascular disease commonly affects the arteries supplying the leg and is mostly caused by atherosclerosis. READ MORE