Search for dissertations about: "neovascularization"

Showing result 6 - 10 of 42 swedish dissertations containing the word neovascularization.

  2. 6. Matrix metalloproteinases and their inhibitors in ocular neovascularization

    Author : Björn Steén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; Neovascularization; Retina; Bruch membrane; Cornea; MMP; TIMP; VEGF; In situ hybridization.;

    Abstract : Growth of pathological new vessels (angiogenesis) in the eye is a leading cause of severe vision-loss. Ocular angiogenesis is seen in the anterior part of the eye as in corneal neovascularization, or in the posterior part as in diabetic retinopathy, retinopathy of prematurity or age-related macular degeneration. READ MORE

  4. 7. Choroidal neovascularization (CNV) : clinical and experimental aspects

    Author : Lennart Berglin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CNV; angiogenesis; age-related macular degeneration; AMD; aging; surgery; endothelial cells; VEGF; MMP; TIMP; MMP-2; immunohistochemistry; ECM; RPE; Bruch s membrane; wound healing; inflammation; macrophages; in-situ hybridization; mRNA; immature vessels; MMP-9; TIMP- 3; MMP-2 deficiency;

    Abstract : This work comprises different aspects of choroidal neovacularization (CNV); a leading cause of visual loss in the aged. It is an example of angiogenesis and a complication of age-related macular degeneration (AMD) The purpose was to study if patient age influences outcome of CNV surgery, to characterize the cellular content of CNV, to analyze the expression of vascular endothelial growth factor (VEGF) and various matrix metalloproteinases (MMP) and their inhibitors (TIMP) in CNV and to study if MMP-2 influences experimental CNV growth. READ MORE

  5. 8. Angiogenesis in childhood malignancies

    Author : Erik Sköldenberg; Rolf Christofferson; Göran Läckgren; Agneta Nordenskjöld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Angiogenesis Factor; Biopsy; Needle; Neovascularization; Pathologic; Nephroblastoma; Reference value; Kirurgi; Surgery; Kirurgi; Pediatric Surgery; kirurgi; särskilt barnkirurgi;

    Abstract : Angiogenesis is necessary for the growth and spread of solid tumors. In these studies angiogenesis was measured in childhood malignancies in general and in Wilms’ tumor in particular, and cutting needle biopsy (CNB) specimens were evaluated for diagnosis in childhood renal tumors. READ MORE

  6. 9. Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina

    Author : Parviz Mammadzada; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying mechanisms are complex. READ MORE

  7. 10. Positive and negative angiogenic factors in patients with malignant disease

    Author : Christina Linder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : angiogenesis; neovascularization; microvessel density; VEGF; bFGF; stromelysin-3;

    Abstract : In this thesis, the levels of positive and negative angiogenic factors were studied in tissue, serum and urine from patients with malignant disease. The angiogenic factors VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) were studied in breast carcinomas. READ MORE