Search for dissertations about: "nerve-agent"

Found 4 swedish dissertations containing the word nerve-agent.

  2. 1. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase

    Author : Cecilia Lindgren; Anna Linusson; Antti Poso; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; class II MHC protein; drug design; molecular dynamics simulation; multicomponent system; nerve agent; oxime; quantitative structure-activity relationship; reactivator; rheumatoid arthritis; statistical molecular design; T-cell receptor;

    Abstract : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. READ MORE

  4. 2. Exploring non-covalent interactions between drug-like molecules and the protein acetylcholinesterase

    Author : Lotta Berg; Anna Linusson; Fredrik Ekström; Joel L. Sussman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; drug discovery; density functional theory; hydrogen bond; nerve-agent antidote; non-covalent interaction; protein-ligand complex; structure-based design; thermodynamics; X-ray crystallography; datorlingvistik; computational linguistics;

    Abstract : The majority of drugs are small organic molecules, so-called ligands, that influence biochemical processes by interacting with proteins. The understanding of how and why they interact and form complexes is therefore a key component for elucidating the mechanism of action of drugs. READ MORE

  5. 3. Simplified Routines for Sample Preparation and Analysis of Chemical Warfare Agent Degradation Products

    Author : Raja Subramaniam; Calle Nilsson; Paula Vanninen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nerve agents; Alkyl alkylphosphonic acids; Solid phase derivatization; Fluorinated diazomethane reagent; High-energy collision induced dissociation; CID MS MS library; analytisk kemi; Analytical Chemistry;

    Abstract : The thesis describes the development of new and improved methods for analyzing degradation markers from organophosphorus Chemical Warfare Agents (CWAs). Paper I and II describes an innovative and significantly improved method for the enrichment, derivatization (trimethysilylation) and GC-MS analysis of a broad range of organophosphorus CWAs degradation markers, namely the alkylphosphonic acids and a zwitterionic compound. READ MORE

  6. 4. Route attribution of chemical warfare agents : Retrospective classification of unknown threat samples

    Author : Karin Höjer Holmgren; Johan Dahlén; Crister Åstot; Peter Haglund; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Impurity profiling; Chemical attribution signature; Route sourcing;

    Abstract : Although chemical warfare agents (CWAs) are prohibited under international law, there have been numerous crimes that violates the 1997 Chemical Weapons Convention (CWC) during the last decade, especially in the civil war in Syria where sarin, mustard gas and chlorine have all been used. CWAs have also been used in political assassinations and attempts thereof. READ MORE