Search for dissertations about: "neural stem cell"

Showing result 1 - 5 of 219 swedish dissertations containing the words neural stem cell.

  1. 1. Inflammation and Stem Cell Therapy for Stroke

    University dissertation from Lund University, Faculty of Medicine

    Author : Ruimin Ge; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is no treatment that can promote recovery in the chronic phase. It has been shown that neurogenesis occurs in ischemic striatum in rodents and probably also in humans. READ MORE

  2. 2. Neural Stem Cells - interaction with the brain and prospects for cell replacement therapy for Stroke

    University dissertation from Neural stem cell biology and therapy

    Author : Emanuela Monni; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural stem cells; human; fetus; cortex; striatum; stroke; transplantation; inflammation; fusion; reprogramming; chimera; heterokaryon;

    Abstract : Popular Abstract in Swedish Stroke är ett akut neurologiskt tillstånd och den främsta anledningen till funktionsnedsättning hos vuxna. Det finns ingen behandling för effektiv återhämtning. Den vanligaste formen av stroke orsakas av att mellersta storhjärnsartären blockeras vilket gör att man förlorar hjärnceller, till exempel neuroner. READ MORE

  3. 3. Downstream effects of master regulators in two brain diseases

    University dissertation from Neural stem cell biology and therapy

    Author : Sebastian Braun; Lunds universitet.; Lund University.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rett syndrome; brain tumor development; gene regulation; neural stem cells; cell of origin; BMI1;

    Abstract : In paper one, we investigated how the pharmacological activation and inhibition of the glucocorticoid system affects lifespan and symptoms in a mouse model for RTT. We performed a long-term drug treatment study with the GR activator corticosterone and the GR inhibitor RU486 under which we measured the lifespan and onset of RTT-like symptoms of male Mecp2-null and female Mecp2 heterozygous mice in comparison to untreated mutant and to treated and untreated wild-type animals. READ MORE

  4. 4. Novel Regulators of Brain Tumor Development – From neural stem cell differentiation to in vivo models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anqi Xiong; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

    Abstract : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. READ MORE

  5. 5. Modeling Neural Stem Cell and Glioma Biology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tobias Bergström; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; integrins; glioma; PDGF; mast cell; Molekylär cellbiologi; Molecular Cellbiology; Oncology; Onkologi;

    Abstract : This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact with extracellular matrix (ECM) proteins in the stem cell niche, and investigate the consequences of deregulated Platelet-derived growth factor (PDGF) signaling for embryonic NSCs in transgenic mice. READ MORE