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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Anabolic Androgenic Steroids : Neurobiological Effects of Nandrolone, Testosterone, Trenbolone, and Stanozolol

    Author : Sofia Zelleroth; Mathias Hallberg; Astrid Bjørnebekk; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anabolic androgenic steroids; testosterone; nandrolone; trenbolone; stanozolol; central nervous system; primary cortical cell cultures; rats; multivariate concentric square field; novel object recognition.; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The use of anabolic androgenic steroids (AAS) for recreational purposes is a health concern, as long-term AAS-use in supraphysiological doses is associated with severe physical and psychological adverse effects. Several behavioral and cognitive problems are reported after long-term AAS-use, and alterations in brain morphology as well as neurotransmitter systems have been reported. READ MORE

  4. 2. Trophic factors, neuroprotection and spinal cord repair

    Author : Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Abstract : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. READ MORE

  5. 3. Neurotrophic factors and neuronal plasticity

    Author : Sten Linnarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The neurotrophic factors were originally discovered because of their ability to rescue neurons during a period of naturally occurring programmed cell death. This gave rise to the neurotrophic factor hypothesis which states that specific target-derived factors protect and support subpopulations of innervating neurons, thereby regulating the pattern and quantity of innervation properly for each target tissue. READ MORE

  6. 4. Schwann cells and mesenchymal stem cells as promoter of peripheral nerve regeneration

    Author : Maria Cristina Mantovani; Mikael Wiberg; Giorgio Terenghi; Susan Shawcross; Lev Novikov; Liudmila Novikova; John W Haycock; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve regeneration; Schwann cell; adult stem cell; myelin; senescence;

    Abstract : The transplantation of primary Schwann cells (SC) has been shown to improve nerve regeneration. However, to monitor the survival of transplanted cells within the host, a stable labelling method is required. READ MORE

  7. 5. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

    Author : Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. READ MORE